Graphene/tri-block copolymer composites prepared via RAFT polymerizations for dual controlled drug delivery via pH stimulation and biodegradation

Song, Zhongqian, Xu, Yuanhong, Yang, Wenrong, Cui, Liang, Zhang, Jizhen and Liu, Jigquan 2015, Graphene/tri-block copolymer composites prepared via RAFT polymerizations for dual controlled drug delivery via pH stimulation and biodegradation, European polymer journal, vol. 69, pp. 559-572, doi: 10.1016/j.eurpolymj.2015.02.014.

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Title Graphene/tri-block copolymer composites prepared via RAFT polymerizations for dual controlled drug delivery via pH stimulation and biodegradation
Author(s) Song, Zhongqian
Xu, Yuanhong
Yang, WenrongORCID iD for Yang, Wenrong orcid.org/0000-0001-8815-1951
Cui, Liang
Zhang, Jizhen
Liu, Jigquan
Journal name European polymer journal
Volume number 69
Start page 559
End page 572
Total pages 14
Publisher Elsevier
Place of publication Amsterdam, The Netherlands
Publication date 2015
ISSN 0014-3057
Keyword(s) Biodegradable release
Drug delivery
Graphene
PH-responsive
RAFT polymerization
π-π stacking interaction
Summary A novel tri-block copolymer poly(oxopentanoate ethyl methacrylate)-block-poly(pyridyl disulfide ethyl acrylate)-block-poly(ethylene glycol acrylate) [poly(OEMA-b-PDEA-b-PEGA)], retaining active keto groups and pyridyl disulfide (PDS) side functionalities, was synthesized as a drug delivery vehicle using reversible addition-fragmentation chain transfer (RAFT) polymerization method. One mimic drug pyridine-2-thione (PT) was introduced into the monomer, PDEA for copolymerization. The other mimic drug O-benzylhydroxylamine (BHA) was conjugated with tri-block copolymer via efficient oxime coupling chemistry, followed by the attachment onto graphene via π-π stacking interaction to obtain a graphene/tri-block copolymer composite. 1H NMR, UV-vis absorption spectroscopy, fluorescence spectroscopy, gel permeation chromatography (GPC), atomic force microscope (AFM) and transmission electron microscope (TEM) were used to verify the successful step-wise preparation of the tri-block copolymer and drug loaded composite. In vitro release behaviors of BHA and PT from graphene/tri-block copolymer composite via dual drug release mechanisms were investigated. BHA can be released under acid environment, while PT will be released in the presence of reducing agents, such as dithiothreitol (DTT) or glutathione (GSH). It can be envisioned that this novel composite could be exploited as a novel intracellular drug delivery system via dual release mechanisms.
Language eng
DOI 10.1016/j.eurpolymj.2015.02.014
Field of Research 030302 Nanochemistry and Supramolecular Chemistry
Socio Economic Objective 970103 Expanding Knowledge in the Chemical Sciences
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2015, Elsevier
Persistent URL http://hdl.handle.net/10536/DRO/DU:30072412

Document type: Journal Article
Collection: School of Life and Environmental Sciences
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