Lubricin: a versatile, biological anti-adhesive with properties comparable to polyethylene glycol

Greene, George W., Martin, Lisandra L., Tabor, Rico F., Michalczyk, Agnes, Ackland, Leigh M. and Horn, Roger 2015, Lubricin: a versatile, biological anti-adhesive with properties comparable to polyethylene glycol, Biomaterials, vol. 53, pp. 127-136.

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Title Lubricin: a versatile, biological anti-adhesive with properties comparable to polyethylene glycol
Author(s) Greene, George W.ORCID iD for Greene, George W.
Martin, Lisandra L.
Tabor, Rico F.
Michalczyk, AgnesORCID iD for Michalczyk, Agnes
Ackland, Leigh M.ORCID iD for Ackland, Leigh M.
Horn, Roger
Journal name Biomaterials
Volume number 53
Start page 127
End page 136
Total pages 10
Publisher Elsevier
Place of publication Amsterdam, The Netherlands
Publication date 2015-06
ISSN 1878-5905
Keyword(s) Anti-adhesion
Non-specific binding
Quartz crystal microbalance
Surface treatment
Science & Technology
Engineering, Biomedical
Materials Science, Biomaterials
Materials Science
Summary Lubricin is a glycoprotein found in articular joints which has been recognized as being an important biological boundary lubricant molecule. Besides providing lubrication, we demonstrate, using a quartz crystal microbalance, that lubricin also exhibits anti-adhesive properties and is highly effective at preventing the non-specific adsorption of representative globular proteins and constituents of blood plasma. This impressive anti-adhesive property, combined with lubricin's ability to readily self-assemble to form dense, highly stable telechelic polymer brush layers on virtually any substrates, and its innate biocompatibility, makes it an attractive candidate for anti-adhesive and anti-fouling coatings. We show that coatings of lubricin protein are as effective as, or better than, self-assembled monolayers of polyethylene glycol over a wide range of pH and that this provides a simple, versatile, highly stable, and highly effective method of controlling unwanted adhesion to surfaces.
Language eng
Field of Research 090301 Biomaterials
090304 Medical Devices
100402 Medical Biotechnology Diagnostics (incl Biosensors)
100703 Nanobiotechnology
Socio Economic Objective 970106 Expanding Knowledge in the Biological Sciences
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Grant ID DE130101458
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