The influence of titania-zirconia-zirconium titanate nanotube characteristics on osteoblast cell adhesion

Minagar, Sepideh, Li, Yuncang, Berndt, Christopher C. and Wen, Cuie 2015, The influence of titania-zirconia-zirconium titanate nanotube characteristics on osteoblast cell adhesion, Acta biomaterialia, vol. 12, pp. 281-289, doi: 10.1016/j.actbio.2014.10.037.

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Title The influence of titania-zirconia-zirconium titanate nanotube characteristics on osteoblast cell adhesion
Author(s) Minagar, Sepideh
Li, Yuncang
Berndt, Christopher C.
Wen, Cuie
Journal name Acta biomaterialia
Volume number 12
Start page 281
End page 289
Total pages 9
Publisher Elsevier
Place of publication Amsterdam, The Netherlands
Publication date 2015-01-15
ISSN 1742-7061
Keyword(s) nanotube
titania (TiO(2))
zirconia (ZrO(2))
zirconium titanate (ZrTiO(4))
osteoblast cell response
Summary Studies of biomaterial surfaces and their influence on cell behavior provide insights concerning the design of surface physicochemical and topography properties of implant materials. Fabrication of biocompatible metal oxide nanotubes on metallic biomaterials, especially titanium alloys such as Ti50Zr via anodization, alters the surface chemistry as well as surface topography of the alloy. In this study, four groups of TiO2-ZrO2-ZrTiO4 nanotubes that exhibit diverse nanoscale dimensional characteristics (i.e. inner diameter Di, outer diameter Do and wall thicknesses Wt) were fabricated via anodization. The nanotubes were annealed and characterized using scanning electron microscopy and 3-D profilometry. The potential applied during anodization influenced the oxidation rate of titanium and zirconium, thereby resulting in different nanoscale characteristics for the nanotubes. The different oxidation and dissolution rates both led to changes in the surface roughness parameters. The in vitro cell response to the nanotubes with different nanoscale dimensional characteristics was assessed using osteoblast cells (SaOS2). The results of the MTS assay indicated that the nanotubes with inner diameter (Di)≈40nm exhibited the highest percentage of cell adhesion of 41.0%. This result can be compared to (i) 25.9% cell adhesion at Di≈59nm, (ii) 33.1% at Di≈64nm, and (iii) 33.5% at Di≈82nm. The nanotubes with Di≈59nm exhibited the greatest roughness parameter of Sa (mean roughness), leading to the lowest ability to interlock with SaOS2 cells.
Language eng
DOI 10.1016/j.actbio.2014.10.037
Field of Research 030302 Nanochemistry and Supramolecular Chemistry
Socio Economic Objective 970103 Expanding Knowledge in the Chemical Sciences
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2014, Acta Materialia
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