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Interleukin-10 inhibits bone resorption: a potential therapeutic strategy in periodontitis and other bone loss diseases

Zhang,Q, Chen,B, Yan,F, Guo,J, Zhu,X, Ma,S and Yang,W 2014, Interleukin-10 inhibits bone resorption: a potential therapeutic strategy in periodontitis and other bone loss diseases, BioMed research international, vol. 2014, pp. 1-6, doi: 10.1155/2014/284836.

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Title Interleukin-10 inhibits bone resorption: a potential therapeutic strategy in periodontitis and other bone loss diseases
Author(s) Zhang,Q
Chen,B
Yan,F
Guo,J
Zhu,X
Ma,S
Yang,WORCID iD for Yang,W orcid.org/0000-0001-8815-1951
Journal name BioMed research international
Volume number 2014
Start page 1
End page 6
Publisher Hindawi Publishing Corporation
Place of publication New York, NY
Publication date 2014
ISSN 2314-6141
2314-6141
Summary Periodontitis and other bone loss diseases, decreasing bone volume and strength, have a significant impact on millions of people with the risk of tooth loss and bone fracture. The integrity and strength of bone are maintained through the balance between bone resorption and bone formation by osteoclasts and osteoblasts, respectively, so the loss of bone results from the disruption of such balance due to increased resorption or/and decreased formation of bone. The goal of therapies for diseases of bone loss is to reduce bone loss, improve bone formation, and then keep healthy bone density. Current therapies have mostly relied on long-term medication, exercise, anti-inflammatory therapies, and changing of the life style. However there are some limitations for some patients in the effective treatments for bone loss diseases because of the complexity of bone loss. Interleukin-10 (IL-10) is a potent anti-inflammatory cytokine, and recent studies have indicated that IL-10 can contribute to the maintenance of bone mass through inhibition of osteoclastic bone resorption and regulation of osteoblastic bone formation. This paper will provide a brief overview of the role of IL-10 in bone loss diseases and discuss the possibility of IL-10 adoption in therapy of bone loss diseases therapy.
Language eng
DOI 10.1155/2014/284836
Field of Research 119999 Medical and Health Sciences not elsewhere classified
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2014, Hindawi
Persistent URL http://hdl.handle.net/10536/DRO/DU:30072613

Document type: Journal Article
Collections: School of Life and Environmental Sciences
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Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.