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Inhibition of HIV-1 replication by balsamin, a ribosome inactivating protein of Momordica balsamina

Kaur, Inderdeep, Puri, Munish, Ahmed, Zahra, Blanchet, Fabien P., Mangeat, Bastien and Piguet, Vincent 2013, Inhibition of HIV-1 replication by balsamin, a ribosome inactivating protein of Momordica balsamina, PLoS One, vol. 8, no. 9, pp. 1-9, doi: 10.1371/journal.pone.0073780.

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Title Inhibition of HIV-1 replication by balsamin, a ribosome inactivating protein of Momordica balsamina
Formatted title Inhibition of HIV-1 replication by balsamin, a ribosome inactivating protein of Momordica balsamina
Author(s) Kaur, Inderdeep
Puri, MunishORCID iD for Puri, Munish orcid.org/0000-0003-2469-3326
Ahmed, Zahra
Blanchet, Fabien P.
Mangeat, Bastien
Piguet, Vincent
Journal name PLoS One
Volume number 8
Issue number 9
Article ID e73780
Start page 1
End page 9
Total pages 9
Publisher Public Library of Science (PLOS)
Place of publication San Francisco, Calif.
Publication date 2013-09
ISSN 1932-6203
Summary Ribosome-inactivating proteins (RIPs) are endowed with several medicinal properties, including antiviral activity. We demonstrate here that the recently identified type I RIP from Momordica balsamina also possesses antiviral activity, as determined by viral growth curve assays and single-round infection experiments. Importantly, this activity is at play even as doses where the RIP has no cytotoxic effect. In addition, balsamin inhibits HIV-1 replication not only in T cell lines but also in human primary CD4(+) T cells. This antiviral compound exerts its activity at a viral replicative step occurring later than reverse-transcription, most likely on viral protein translation, prior to viral budding and release. Finally, we demonstrate that balsamin antiviral activity is broad since it also impedes influenza virus replication. Altogether our results demonstrate that type I RIP can exert a potent anti-HIV-1 activity which paves the way for new therapeutic avenues for the treatment of viral infections.
Language eng
DOI 10.1371/journal.pone.0073780
Field of Research 100302 Bioprocessing, Bioproduction and Bioproducts
Socio Economic Objective 970110 Expanding Knowledge in Technology
HERDC Research category C1.1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2013, The Authors
Free to Read? Yes
Use Rights Creative Commons Attribution licence
Persistent URL http://hdl.handle.net/10536/DRO/DU:30072933

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Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.