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Targeting the sodium iodide symporter (NIS) and apoptotic genes in extrathyroidal tumors.

Samuel, Jaisy 2014, Targeting the sodium iodide symporter (NIS) and apoptotic genes in extrathyroidal tumors., PhD thesis, School of Medicine, Deakin University.

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Title Targeting the sodium iodide symporter (NIS) and apoptotic genes in extrathyroidal tumors.
Author Samuel, Jaisy
Institution Deakin University
School School of Medicine
Faculty Faculty of Health
Degree type Research doctorate
Degree name PhD
Thesis advisor Kanwar (nee Kaur), Rupinder
Kanwar, Jagat
Date submitted 2014-08
Keyword(s) sodium iodide symporter (NIS)
extrathyroidal tumors
thyroid cancer
breast cancer
retinoblastoma
apoptotic genes
Summary Sodium Iodide Symporter (NIS), a therapeutic gene, was studied for the first time in retinoblastoma (RB) correlating the expression with clinicopathological invasiveness of the tumor. The specificity of EpCAM based NIS gene therapy was demonstrated in breast cancer cell as a proof of concept model via 1) EpCAM as tissue specific promoter and 2) nanoformulation, both of which showed encouraging outcomes. In addition, for the first time the upregulated expression of splice variants of survivin, Bax and Bcl-2 in RB tumors was explored indicating their possible role in tumor progression through apoptosis dysregulation. Thus, the above study achieved a profound knowledge about NIS and apoptotic genes in extrathyroidal tumors.
Language eng
Field of Research 111208 Radiation Therapy
111207 Molecular Targets
100709 Nanomedicine
Socio Economic Objective 920102 Cancer and Related Disorders
Description of original xv, 302 pages : illustrations, tables, graphs
Dewey Decimal Classification 616.99406
Restricted until 2017-02-13
Copyright notice ┬ęThe author
Free to Read? No
Free to Read Start Date 2016-05-19
Persistent URL http://hdl.handle.net/10536/DRO/DU:30072981

Document type: Thesis
Collection: Higher degree theses (citation only)
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Created: Wed, 06 May 2015, 09:51:00 EST by Kate Percival

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