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Lower protein-to-carbohydrate ratio in maternal diet is associated with higher childhood systolic blood pressure up to age four years

Blumfield, Michelle L., Nowson, Caryl, Hure, Alexis J., Smith, Roger, Simpson, Stephen J., Raubenheimer, David, MacDonald-Wicks, Lesley and Collins, Clare E. 2015, Lower protein-to-carbohydrate ratio in maternal diet is associated with higher childhood systolic blood pressure up to age four years, Nutrients, vol. 7, no. 5, pp. 3078-3093, doi: 10.3390/nu7053078.

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Title Lower protein-to-carbohydrate ratio in maternal diet is associated with higher childhood systolic blood pressure up to age four years
Author(s) Blumfield, Michelle L.
Nowson, CarylORCID iD for Nowson, Caryl orcid.org/0000-0001-6586-7965
Hure, Alexis J.
Smith, Roger
Simpson, Stephen J.
Raubenheimer, David
MacDonald-Wicks, Lesley
Collins, Clare E.
Journal name Nutrients
Volume number 7
Issue number 5
Start page 3078
End page 3093
Total pages 16
Publisher MDPI
Place of publication Basel, Switzerland
Publication date 2015
ISSN 2072-6643
Summary The prenatal environment can influence development of offspring blood pressure (BP), which tracks into adulthood. This prospective longitudinal study investigated whether maternal pregnancy dietary intake is associated with the development of child BP up to age four years. Data are from 129 mother-child dyads enrolled in the Women and Their Children's Health study. Maternal diet was assessed using a validated 74-item food frequency questionnaire at 18 to 24 weeks and 36 to 40 weeks, with a reference period of the previous three months. Child systolic and diastolic BP were measured at 3, 6, 9, 12, 24, 36 and 48 months, using an automated BP monitor. Using mixed-model regression analyses adjusted for childhood growth indices, pregnancy intakes of percentage of energy (E%) polyunsaturated fat (β coefficient 0.73; 95% CI 0.003, 1.45; p = 0.045), E% omega-6 fatty acids (β coefficient 0.89; 95% CI 0.09, 1.69; p = 0.03) and protein-to-carbohydrate (P:C) ratio (β coefficient -14.14; 95% CI -27.68, -0.60; p = 0.04) were associated with child systolic BP trajectory up to 4 years. Child systolic BP was greatest at low proportions of dietary protein (<16% of energy) and high carbohydrate (>40% of energy) intakes. There may be an ideal maternal macronutrient ratio associated with optimal infant BP. Maternal diet, which is potentially modifiable, may play an important role in influencing offspring risk of future hypertension.
Notes Reproduced with the kind permission of the copyright owner.
Language eng
DOI 10.3390/nu7053078
Field of Research 090899 Food Sciences not elsewhere classified
Socio Economic Objective 920411 Nutrition
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2015, MDPI
Persistent URL http://hdl.handle.net/10536/DRO/DU:30072989

Document type: Journal Article
Collections: School of Exercise and Nutrition Sciences
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Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.