Locked nucleic acid aptamer based microfluidic devices for capturing tumor cells

Maremanda, Nihal Ganesh 2014, Locked nucleic acid aptamer based microfluidic devices for capturing tumor cells, Ph.D. thesis, School of Medicine, Deakin University.

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Title Locked nucleic acid aptamer based microfluidic devices for capturing tumor cells
Author Maremanda, Nihal Ganesh
Institution Deakin University
School School of Medicine
Faculty Faculty of Health
Degree type Research doctorate
Degree name Ph.D.
Thesis advisor Kanwar JagatORCID iD for Kanwar Jagat orcid.org/0000-0003-3728-9568
Kanwar (nee Kaur), Rupinder
Date submitted 2014-07
Keyword(s) cancer diagnosis
cancer prognosis
cancer therapy
microfluidic devices
protein markers
biomarkers
locked nucleic acid
Summary Design and fabrication of novel microfluidic devices for sensitive and specific capture of circulating tumor cells using locked nucleic acid modified aptamers and antibodies targeting EpCAM/Nucleolin expression. These devices also allow re-usability, on-chip characterization of multiple markers and release of viable captured cells for further culture and in vitro characterization for cancer diagnosis, prognosis and therapeutic planning.
Language eng
Field of Research 100709 Nanomedicine
Socio Economic Objective 920102 Cancer and Related Disorders
Description of original xx, 315 pages : illustrations, some coloured
Dewey Decimal Classification 614.5999
Restricted until 2020-09-01
Copyright notice ┬ęThe Author. All Rights Reserved
Persistent URL http://hdl.handle.net/10536/DRO/DU:30073093

Document type: Thesis
Collection: Higher degree theses (citation only)
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