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Multivitamin-multimineral supplementation and mortality: a meta-analysis of randomized controlled trials

Macpherson,H, Pipingas,A and Pase,MP 2013, Multivitamin-multimineral supplementation and mortality: a meta-analysis of randomized controlled trials, American journal of clinical nutrition, vol. 97, no. 2, pp. 437-444, doi: 10.3945/ajcn.112.049304.

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Title Multivitamin-multimineral supplementation and mortality: a meta-analysis of randomized controlled trials
Author(s) Macpherson,HORCID iD for Macpherson,H orcid.org/0000-0002-3603-9359
Pipingas,A
Pase,MP
Journal name American journal of clinical nutrition
Volume number 97
Issue number 2
Start page 437
End page 444
Total pages 8
Publisher American Society for Nutrition
Place of publication Washington, D.C.
Publication date 2013-02
ISSN 1938-3207
Keyword(s) Science & Technology
Life Sciences & Biomedicine
Nutrition & Dietetics
PLACEBO-CONTROLLED TRIAL
ANTIOXIDANT VITAMIN SUPPLEMENTATION
TRACE-ELEMENT SUPPLEMENTATION
NUTRITION INTERVENTION TRIALS
PRECANCEROUS GASTRIC-LESIONS
DISEASE-SPECIFIC MORTALITY
ALL-CAUSE MORTALITY
IOWA WOMENS-HEALTH
CANCER INCIDENCE
OLDER-PEOPLE
Summary BACKGROUND: Multivitamins are the most commonly used supplement in the developed world. Recent epidemiologic findings suggest that multivitamin use increases the risk of mortality. OBJECTIVE: We aimed to determine whether multivitamin-multimineral treatment, used for primary or secondary prevention, increases the risk of mortality in independently living adults. DESIGN: We performed a meta-analysis of randomized controlled trials. Multiple electronic databases were systematically searched from March to October 2012. Randomized controlled primary or secondary prevention trials were considered for inclusion. Eligible trials investigated daily multivitamin-multimineral supplementation for ≥1 y. Cohorts described as institutionalized or as having terminal illness (tertiary prevention) were excluded. The number of deaths and the sample size of each study arm were extracted independently by 2 researchers. Twenty-one articles were included in the analysis, which generated a total pooled sample of 91,074 people and 8794 deaths. These trials were pooled in a meta-analysis, and the outcomes were expressed as RRs and 95% CIs. RESULTS: The average age of the pooled sample was 62 y, and the average duration of supplementation was 43 mo. Across all studies, no effect of multivitamin-multimineral treatment on all-cause mortality (RR: 0.98; 95% CI: 0.94, 1.02) was observed. There was a trend for a reduced risk of all-cause mortality across primary prevention trials (RR: 0.94; 95% CI: 0.89, 1.00). Multivitamin-multimineral treatment had no effect on mortality due to vascular causes (RR: 1.01; 95% CI: 0.93, 1.09) or cancer (RR: 0.96; 95% CI: 0.88, 1.04). No statistical evidence of heterogeneity or publication bias was observed. CONCLUSION: Multivitamin-multimineral treatment has no effect on mortality risk.
Language eng
DOI 10.3945/ajcn.112.049304
Field of Research 111102 Dietetics and Nutrigenomics
Socio Economic Objective 920411 Nutrition
HERDC Research category C1.1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2013, American Society for Nutrition
Free to Read? Yes
Persistent URL http://hdl.handle.net/10536/DRO/DU:30073126

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Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.