Glucose enhancement of recognition memory: differential effects on effortful processing but not aspects of 'remember-know' responses

Scholey,A, Macpherson,H, Sünram-Lea,S, Elliott,J, Stough,C and Kennedy,D 2013, Glucose enhancement of recognition memory: differential effects on effortful processing but not aspects of 'remember-know' responses, Neuropharmacology, vol. 64, pp. 544-549, doi: 10.1016/j.neuropharm.2012.06.030.

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Title Glucose enhancement of recognition memory: differential effects on effortful processing but not aspects of 'remember-know' responses
Author(s) Scholey,A
Macpherson,HORCID iD for Macpherson,H
Journal name Neuropharmacology
Volume number 64
Start page 544
End page 549
Total pages 6
Publisher Elsevier
Place of publication Amsterdam, The Netherlands
Publication date 2013-01
ISSN 1873-7064
Keyword(s) Familiarity
Mental effort
Recognition memory
Science & Technology
Life Sciences & Biomedicine
Pharmacology & Pharmacy
Neurosciences & Neurology
Summary The administration of a glucose drink has been shown to enhance cognitive performance with effect sizes comparable with those from pharmaceutical interventions in human trials. In the memory domain, it is currently debated whether glucose facilitation of performance is due to differential targeting of hippocampal memory or whether task effort is a more important determinant. Using a placebo-controlled, double-blind, crossover 2(Drink: glucose/placebo) × 2(Effort: ± secondary task) design, 20 healthy young adults' recognition memory performance was measured using the 'remember-know' procedure. Two high effort conditions (one for each drink) included secondary hand movements during word presentation. A 25 g glucose or 30 mg saccharine (placebo) drink was consumed 10 min prior to the task. The presence of a secondary task resulted in a global impairment of memory function. There were significant Drink × Effort interactions for overall memory accuracy but no differential effects for 'remember' or 'know' responses. These data suggest that, in some circumstances, task effort may be a more important determinant of the glucose facilitation of memory effect than hippocampal mediation. This article is part of a Special Issue entitled 'Cognitive Enhancers'.
Language eng
DOI 10.1016/j.neuropharm.2012.06.030
Field of Research 170299 Cognitive Science not elsewhere classified
Socio Economic Objective 920411 Nutrition
HERDC Research category C1.1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2013, Elsevier
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Document type: Journal Article
Collections: Faculty of Health
School of Exercise and Nutrition Sciences
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