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Effects of a multivitamin, mineral and herbal supplement on cognition and blood biomarkers in older men: a randomised, placebo-controlled trial

Harris,E, Macpherson,H, Vitetta,L, Kirk,J, Sali,A and Pipingas,A 2012, Effects of a multivitamin, mineral and herbal supplement on cognition and blood biomarkers in older men: a randomised, placebo-controlled trial, Human psychopharmacology, vol. 27, no. 4, pp. 370-377, doi: 10.1002/hup.2236.

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Title Effects of a multivitamin, mineral and herbal supplement on cognition and blood biomarkers in older men: a randomised, placebo-controlled trial
Author(s) Harris,E
Macpherson,HORCID iD for Macpherson,H orcid.org/0000-0002-3603-9359
Vitetta,L
Kirk,J
Sali,A
Pipingas,A
Journal name Human psychopharmacology
Volume number 27
Issue number 4
Start page 370
End page 377
Total pages 8
Publisher Wiley
Place of publication London, Eng.
Publication date 2012-07
ISSN 1099-1077
Keyword(s) folate
multivitamin
Science & Technology
Social Sciences
Life Sciences & Biomedicine
Clinical Neurology
Pharmacology & Pharmacy
Psychiatry
Psychology
Neurosciences & Neurology
PSYCHIATRY, SCI
FOLIC-ACID
ALZHEIMER-DISEASE
VITAMIN STATUS
GINKGO-BILOBA
LIFE-SPAN
PERFORMANCE
ADULTS
WOMEN
Summary OBJECTIVE: Nutritional and vitamin status may be related to cognitive function and decline in older adults. The aim of this study was to investigate the effects of nutritional supplementation on cognition in older men. METHOD: The current study was an 8-week, placebo-controlled, double-blind investigation into the effects of a multivitamin, mineral and herbal supplement (Swisse Men's Ultivite®, Swisse Vitamins Pty Ltd, Melbourne, Australia) on cognitive performance in older men. Participants were 51 male individuals aged between 50 and 74 years, with a sedentary lifestyle. Cognitive performance was assessed at baseline and post-treatment using a computerised battery of cognitive tasks, enabling the measurement of a range of attentional and memory processes. Blood measures of vitamin B(12) , folate and homocysteine were collected prior to and after supplementation. RESULTS: The results of this study revealed that contextual recognition memory performance was significantly improved following multivitamin supplementation (p < 0.05). Performance on other cognitive tasks did not change. Levels of vitamin B(12) and folate were significantly increased with a concomitant decrease in homocysteine, indicating that relatively short-term supplementation with a multivitamin can benefit these risk factors for cognitive decline. CONCLUSION: Findings from this study indicate that daily multivitamin supplementation may improve episodic memory in older men at risk of cognitive decline.
Language eng
DOI 10.1002/hup.2236
Field of Research 111199 Nutrition and Dietetics not elsewhere classified
Socio Economic Objective 920411 Nutrition
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2012, Wiley
Persistent URL http://hdl.handle.net/10536/DRO/DU:30073129

Document type: Journal Article
Collection: School of Exercise and Nutrition Sciences
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