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Memory improvements in elderly women following 16 weeks treatment with a combined multivitamin, mineral and herbal supplement: a randomized controlled trial.

Macpherson,H, Ellis,KA, Sali,A and Pipingas,A 2012, Memory improvements in elderly women following 16 weeks treatment with a combined multivitamin, mineral and herbal supplement: a randomized controlled trial., Psychopharmacology, vol. 220, no. 2, pp. 351-365, doi: 10.1007/s00213-011-2481-3.

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Title Memory improvements in elderly women following 16 weeks treatment with a combined multivitamin, mineral and herbal supplement: a randomized controlled trial.
Author(s) Macpherson,HORCID iD for Macpherson,H orcid.org/0000-0002-3603-9359
Ellis,KA
Sali,A
Pipingas,A
Journal name Psychopharmacology
Volume number 220
Issue number 2
Start page 351
End page 365
Total pages 15
Publisher Springer
Place of publication Berlin, Germany
Publication date 2012-03
ISSN 1432-2072
Keyword(s) Blood safety
Cognition
Cognitive
Elderly
Inflammation
Memory
Multivitamin
Vitamin
Working memory
Science & Technology
Life Sciences & Biomedicine
Neurosciences
Pharmacology & Pharmacy
Psychiatry
Neurosciences & Neurology
PSYCHIATRY, SCI
FOLIC-ACID SUPPLEMENTATION
COGNITIVE PERFORMANCE
VITAMIN-E
CONTROLLED-TRIAL
BACOPA-MONNIERA
GINKGO-BILOBA
OLDER-PEOPLE
DOUBLE-BLIND
PLASMA HOMOCYSTEINE
Summary RATIONALE: There is potential for multivitamin supplementation to improve cognition in the elderly. This randomized, double-blind, placebo-controlled trial was conducted to investigate the effects of 16 weeks multivitamin supplementation (Swisse Women's 50+ Ultivite ®) on cognition in elderly women. METHODS: Participants in this study were 56 community dwelling, elderly women, with subjective complaints of memory loss. Cognition was assessed using a computerized battery of memory and attention tasks designed to be sensitive to age-related declines to fluid intelligence, and a measure of verbal recall. Biochemical measures of selected nutrients, homocysteine, markers of inflammation, oxidative stress, and blood safety parameters were also collected. All cognitive and haematological parameters were assessed at baseline and 16 weeks post-treatment. RESULTS: The multivitamin improved speed of response on a measure of spatial working memory, however benefits to other cognitive processes were not observed. Multivitamin supplementation decreased levels of homocysteine and increased levels of vitamin B(6) and B(12), with a trend for vitamin E to increase. There were no hepatotoxic effects of the multivitamin formula indicating this supplement was safe for everyday usage in the elderly. CONCLUSION: Sixteen weeks ssupplementation with a combined multivitamin, mineral and herbal formula may benefit working memory in elderly women at risk of cognitive decline.
Language eng
DOI 10.1007/s00213-011-2481-3
Field of Research 170299 Cognitive Science not elsewhere classified
Socio Economic Objective 920410 Mental Health
HERDC Research category C1.1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2012, Springer Verlag
Persistent URL http://hdl.handle.net/10536/DRO/DU:30073134

Document type: Journal Article
Collection: School of Exercise and Nutrition Sciences
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