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The effects of multivitamins on cognitive performance: a systematic review and meta-analysis

Grima,NA, Pase,MP, Macpherson,H and Pipingas,A 2012, The effects of multivitamins on cognitive performance: a systematic review and meta-analysis, Journal of alzheimer's disease, vol. 29, no. 3, pp. 561-569, doi: 10.3233/JAD-2011-111751.

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Title The effects of multivitamins on cognitive performance: a systematic review and meta-analysis
Author(s) Grima,NA
Pase,MP
Macpherson,HORCID iD for Macpherson,H orcid.org/0000-0002-3603-9359
Pipingas,A
Journal name Journal of alzheimer's disease
Volume number 29
Issue number 3
Start page 561
End page 569
Total pages 9
Publisher IOS Press
Place of publication Amsterdam, The Netherlands
Publication date 2012
ISSN 1875-8908
Keyword(s) cognitive
dementia
memory
meta-analysis
multivitamin
nutrients
pharmacology
review
vitamin
Science & Technology
Life Sciences & Biomedicine
Neurosciences
Neurosciences & Neurology
OXIDATIVE STRESS
CONTROLLED-TRIAL
ANTIOXIDANT VITAMINS
ALZHEIMERS-DISEASE
IMPROVES MEMORY
HOMOCYSTEINE
ADULTS
BRAIN
SUPPLEMENTATION
Summary Complementary medicine use is becoming increasingly popular with multivitamins being the most commonly used vitamin supplement. Although adequate vitamin and nutrient concentrations are necessary for optimal health and cognitive functioning, there is no scientific consensus as to whether multivitamin use prevents cognitive decline or improves mental functioning. The aim of the present study was to determine if multivitamins can be used efficaciously to improve cognitive abilities. A systematic review of randomized controlled trials was performed. Meta-analysis was performed on those cognitive tests used across the largest number of studies. Multiple electronic databases were searched until July 2011 by two authors. Randomized, placebo-controlled trials were considered appropriate if they reported on the chronic effects (≥1 month) of oral multivitamin supplementation on any valid cognitive outcomes. Ten trials were included in review (n = 3,200). Meta-analysis indicated that multivitamins were effective in improving immediate free recall memory (SMD = 0.32; 95% CI: 0.09-0.56, p < 0.01) but not delayed free recall memory (SMD = -0.14; 95% CI: -0.43-0.14, p = 0.33) or verbal fluency (SMD = 0.06; 95% CI: -0.05-0.18, p = 0.26). There was no evidence of publication bias or heterogeneity. Other cognitive abilities sensitive to AD pathology, such as executive and visuospatial functions, were found to be under researched. In conclusion, multivitamins were found to enhance immediate free recall memory but no other cognitive domains.
Language eng
DOI 10.3233/JAD-2011-111751
Field of Research 170299 Cognitive Science not elsewhere classified
Socio Economic Objective 920410 Mental Health
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2014, IOS Press
Persistent URL http://hdl.handle.net/10536/DRO/DU:30073136

Document type: Journal Article
Collection: School of Exercise and Nutrition Sciences
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