Predictive factors, efficacy, and safety of balloon post-dilation after transcatheter aortic valve implantation with a balloon-expandable valve

Nombela-Franco, Luis, Rodés-Cabau, Josep, DeLarochellière, Robert, Larose, Eric, Doyle, Daniel, Villeneuve, Jacques, Bergeron, Sebastien, Bernier, Mathieu, Amat-Santos, Ignacio J., Mok, Michael, Urena, Marina, Rheault, Michel, Dumesnil, Jean, Côté, Melanie, Pibarot, Philippe and Dumont, Eric 2012, Predictive factors, efficacy, and safety of balloon post-dilation after transcatheter aortic valve implantation with a balloon-expandable valve, JACC: Cardiovascular interventions, vol. 5, no. 5, pp. 499-512, doi: 10.1016/j.jcin.2012.02.010.

Attached Files
Name Description MIMEType Size Downloads

Title Predictive factors, efficacy, and safety of balloon post-dilation after transcatheter aortic valve implantation with a balloon-expandable valve
Author(s) Nombela-Franco, Luis
Rodés-Cabau, Josep
DeLarochellière, Robert
Larose, Eric
Doyle, Daniel
Villeneuve, Jacques
Bergeron, Sebastien
Bernier, Mathieu
Amat-Santos, Ignacio J.
Mok, MichaelORCID iD for Mok, Michael
Urena, Marina
Rheault, Michel
Dumesnil, Jean
Côté, Melanie
Pibarot, Philippe
Dumont, Eric
Journal name JACC: Cardiovascular interventions
Volume number 5
Issue number 5
Start page 499
End page 512
Total pages 14
Publisher Elsevier
Place of publication Amsterdam, The Netherlands
Publication date 2012-05
ISSN 1936-8798
Keyword(s) aged
aged, 80 and over
aortic valve insufficiency
aortic valve stenosis
cardiac catheterization
cerebrovascular disorders
chi-square distribution
echocardiography, doppler, color
Echocardiography, Transesophageal
Heart Valve Prosthesis
Heart Valve Prosthesis Implantation
Kaplan-Meier Estimate
Logistic Models
Predictive Value of Tests
Prospective Studies
Prosthesis Design
Risk Assessment
Risk Factors
Severity of Illness Index
Time Factors
Tomography, X-Ray Computed
Treatment Outcome
Science & Technology
Life Sciences & Biomedicine
Cardiac & Cardiovascular Systems
Cardiovascular System & Cardiology
balloon post-dilation
transcatheter aortic valve implantation
transcatheter aortic valve replacement
Summary OBJECTIVES: This study sought to evaluate the predictive factors, effects, and safety of balloon post-dilation (BPD) for the treatment of significant paravalvular aortic regurgitation (AR) after transcatheter aortic valve implantation (TAVI). BACKGROUND: Very few data exist on BPD after TAVI with a balloon-expandable valve. METHODS: A total of 211 patients who underwent TAVI with a balloon-expandable valve were included. BPD was performed after TAVI if paravalvular AR ≥ 2 was identified by transesophageal echocardiography. Clinical events and echocardiographic data were prospectively recorded, and median follow-up was 12 (6 to 24) months. RESULTS: BPD was performed in 59 patients (28%), leading to a reduction in at least 1 degree of AR in 71% of patients, with residual AR <2 in 54% of the patients. The predictors of the need for BPD were the degree of valve calcification and transfemoral approach, with valve calcification volume >2,200 and >3,800 mm(3) best determining the need for and a poor response to BPD, respectively. Patients who underwent BPD had a higher incidence of cerebrovascular events at 30 days (11.9% vs. 2.0%, p = 0.006), with most (83%) events within the 24 h after the procedure occurring in patients who had BPD. No significant changes in valve area or AR degree were observed at follow-up in BPD and no-BPD groups. CONCLUSIONS: BPD was needed in about one-fourth of the patients undergoing TAVI with a balloon-expandable valve and was successful in about one-half of them. A higher degree of valve calcification and transfemoral approach predicted the need for BPD. BPD was not associated with any deleterious effect on valve function at mid-term follow-up, but a higher rate of cerebrovascular events was observed in patients who had BPD.
Language eng
DOI 10.1016/j.jcin.2012.02.010
Field of Research 110201 Cardiology (incl Cardiovascular Diseases)
1102 Cardiovascular Medicine And Haematology
Socio Economic Objective 920103 Cardiovascular System and Diseases
HERDC Research category C1.1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2012, American College of Cardiology Foundation
Persistent URL

Document type: Journal Article
Collection: School of Medicine
Connect to link resolver
Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved.

Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 111 times in TR Web of Science
Scopus Citation Count Cited 121 times in Scopus
Google Scholar Search Google Scholar
Access Statistics: 13 Abstract Views, 1 File Downloads  -  Detailed Statistics
Created: Fri, 13 Nov 2015, 12:22:22 EST

Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact