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Birthweight and childhood cancer : preliminary findings from the International Childhood Cancer Cohort Consortium (I4C)

Paltiel, Ora, Tikellis, Gabriella, Linet, Martha, Golding, Jean, Lemeshow, Stanley, Phillips, Gary, Lamb, Karen, Stoltenberg, Camilla, Håberg, Siri E., Strøm, Marin, Granstrøm, Charlotta, Northstone, Kate, Klebanoff, Mark, Ponsonby, Anne-Louise, Milne, Elizabeth, Pedersen, Marie, Kogevinas, Manolis, Ha, Eunhee, Dwyer, Terence and International Childhood Cancer Cohort Consortium 2015, Birthweight and childhood cancer : preliminary findings from the International Childhood Cancer Cohort Consortium (I4C), Paediatric and perinatal epidemiology, vol. 29, no. 4, pp. 335-345, doi: 10.1111/ppe.12193.

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Title Birthweight and childhood cancer : preliminary findings from the International Childhood Cancer Cohort Consortium (I4C)
Author(s) Paltiel, Ora
Tikellis, Gabriella
Linet, Martha
Golding, Jean
Lemeshow, Stanley
Phillips, Gary
Lamb, KarenORCID iD for Lamb, Karen orcid.org/0000-0001-9782-8450
Stoltenberg, Camilla
Håberg, Siri E.
Strøm, Marin
Granstrøm, Charlotta
Northstone, Kate
Klebanoff, Mark
Ponsonby, Anne-Louise
Milne, Elizabeth
Pedersen, Marie
Kogevinas, Manolis
Ha, Eunhee
Dwyer, Terence
International Childhood Cancer Cohort Consortium
Journal name Paediatric and perinatal epidemiology
Volume number 29
Issue number 4
Start page 335
End page 345
Total pages 11
Publisher Wiley
Place of publication London, Eng.
Publication date 2015-07
ISSN 0269-5022
1365-3016
Keyword(s) childhood cancer
cohort studies
leukemia
International Childhood Cancer Cohort Consortium
Summary BACKGROUND: Evidence relating childhood cancer to high birthweight is derived primarily from registry and case-control studies. We aimed to investigate this association, exploring the potential modifying roles of age at diagnosis and maternal anthropometrics, using prospectively collected data from the International Childhood Cancer Cohort Consortium.

METHODS: We pooled data on infant and parental characteristics and cancer incidence from six geographically and temporally diverse member cohorts [the Avon Longitudinal Study of Parents and Children (UK), the Collaborative Perinatal Project (USA), the Danish National Birth Cohort (Denmark), the Jerusalem Perinatal Study (Israel), the Norwegian Mother and Child Cohort Study (Norway), and the Tasmanian Infant Health Survey (Australia)]. Birthweight metrics included a continuous measure, deciles, and categories (≥4.0 vs. <4.0 kilogram). Childhood cancer (377 cases diagnosed prior to age 15 years) risk was analysed by type (all sites, leukaemia, acute lymphoblastic leukaemia, and non-leukaemia) and age at diagnosis. We estimated hazard ratios (HR) and 95% confidence intervals (CI) from Cox proportional hazards models stratified by cohort.

RESULTS: A linear relationship was noted for each kilogram increment in birthweight adjusted for gender and gestational age for all cancers [HR = 1.26; 95% CI 1.02, 1.54]. Similar trends were observed for leukaemia. There were no significant interactions with maternal pre-pregnancy overweight or pregnancy weight gain. Birthweight ≥4.0 kg was associated with non-leukaemia cancer among children diagnosed at age ≥3 years [HR = 1.62; 95% CI 1.06, 2.46], but not at younger ages [HR = 0.7; 95% CI 0.45, 1.24, P for difference = 0.02].

CONCLUSION: Childhood cancer incidence rises with increasing birthweight. In older children, cancers other than leukaemia are particularly related to high birthweight. Maternal adiposity, currently widespread, was not demonstrated to substantially modify these associations. Common factors underlying foetal growth and carcinogenesis need to be further explored.
Language eng
DOI 10.1111/ppe.12193
Field of Research 111299 Oncology and Carcinogenesis not elsewhere classified
111403 Paediatrics
1114 Paediatrics And Reproductive Medicine
1117 Public Health And Health Services
Socio Economic Objective 920102 Cancer and Related Disorders
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2015, The Authors
Free to Read? Yes
Use Rights Creative Commons Attribution licence
Persistent URL http://hdl.handle.net/10536/DRO/DU:30073529

Document type: Journal Article
Collections: School of Exercise and Nutrition Sciences
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Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.