Breakdown in central motor control can be attenuated by motor practice and neuro-modulation of the primary motor cortex

Teo, W. P., Rodrigues, J. P., Mastaglia, F. L. and Thickbroom, G. W. 2012, Breakdown in central motor control can be attenuated by motor practice and neuro-modulation of the primary motor cortex, Neuroscience, vol. 220, pp. 11-18, doi: 10.1016/j.neuroscience.2012.06.048.

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Title Breakdown in central motor control can be attenuated by motor practice and neuro-modulation of the primary motor cortex
Author(s) Teo, W. P.ORCID iD for Teo, W. P.
Rodrigues, J. P.
Mastaglia, F. L.
Thickbroom, G. W.
Journal name Neuroscience
Volume number 220
Start page 11
End page 18
Total pages 8
Publisher Elsevier
Place of publication Amsterdam, The Netherlands
Publication date 2012-09-18
ISSN 0306-4522
Keyword(s) Maximal voluntary rate
Practice-dependent plasticity
Transcranial magnetic stimulation
Spike-timing dependent plasticity
Summary The performance of a repetitive index finger flexion–extension task at maximal voluntary rate (MVR) begins to decline just a few seconds into the task and we have previously postulated that this breakdown has a central origin. To test this hypothesis, we have combined two objectives; to determine whether motor practice can lessen the performance deterioration in an MVR task, and whether further gains can be achieved with a transcranial magnetic stimulation (TMS) protocol that increases corticomotor excitability (CME). Eleven right-handed subjects participated in a randomized crossover study design that consisted of a 15-min interventional TMS at I-wave periodicity (ITMS) and single-pulsed Sham intervention prior to six 10-s practice sets of a repetitive finger flexion–extension task at MVR. Motor-evoked potentials (MEPs) were recorded from the first dorsal interosseous muscle. The starting movement rate, and the percentage decline in rate by the end of the MVR were quantitated. Training of the MVR task improved the sustainability of the task by reducing the decline in movement rate. CME increased steadily after each training bout, and this increase was maintained up to 20 min after the last bout. ITMS further increased CME, and was associated with an increase in both the starting rate of the MVR task and its sustainability, when compared to Sham. The results implicate central motor processes in the performance and sustainability of the MVR task, and indicate that MVR kinematics can improve with short-term training and with non-invasive neuro-modulation.
Language eng
DOI 10.1016/j.neuroscience.2012.06.048
Field of Research 110699 Human Movement and Sports Science not elsewhere classified
Socio Economic Objective 920299 Health and Support Services not elsewhere classified
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2012, Elsevier
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Document type: Journal Article
Collections: Faculty of Health
School of Exercise and Nutrition Sciences
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