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Molecular insights and oligonucleotide based targeted gene therapy against cancer

Subramanian, Nithya 2014, Molecular insights and oligonucleotide based targeted gene therapy against cancer, Ph.D. thesis, School of Medicine, Deakin University.

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Title Molecular insights and oligonucleotide based targeted gene therapy against cancer
Author Subramanian, Nithya
Institution Deakin University
School School of Medicine
Faculty Faculty of Health
Degree type Research doctorate
Degree name Ph.D.
Thesis advisor Kanwar Jagat
Subramanian, Krishnakumar
Kanwar (nee Kaur), Rupinder
Date submitted 2014-10
Keyword(s) retinoblastoma
aptamer
epithelial cancer cells
cancer markers
cancer stem cell
RB
CSC
Summary The thesis helps to unravel the function of T lymphoma invasion and metastasis protein (TIAM1) and nucleolin, a nucleolar protein in retinoblastoma tumorigenesis. Aptamer based targeted imaging; drug and gene delivery to retinoblastoma and epithelial cancer cells was attained. The work work finally opened up avenues for cancer stem cell targeting using aptamers, imaging of cancer cells using novel bio-orthogonal agent and use of aptamer for blocking the miRNA-17-92 cluster maturation.
Language eng
Field of Research 111201 Cancer Cell Biology
111204
Socio Economic Objective 920102 Cancer and Related Disorders
Description of original 297 pages : illustrations ; bibliographical references
Dewey Decimal Classification 571.978
Copyright notice ┬ęThe Author. All Rights Reserved
Free to Read? Yes
Free to Read Start Date 2016-05-01
Persistent URL http://hdl.handle.net/10536/DRO/DU:30073699

Document type: Thesis
Collections: Higher degree theses (full text)
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Created: Thu, 04 Jun 2015, 16:46:40 EST by Kate Percival

Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.