Diffusion tensor imaging reveals no white matter impairments among adults with autism spectrum disorder

Kirkovski, Melissa, Enticott, Peter G., Maller, Jerome J., Rossell, Susan L. and Fitzgerald, Paul B. 2015, Diffusion tensor imaging reveals no white matter impairments among adults with autism spectrum disorder, Psychiatry research - neuroimaging, vol. 233, no. 1, pp. 64-72, doi: 10.1016/j.pscychresns.2015.05.003.

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Title Diffusion tensor imaging reveals no white matter impairments among adults with autism spectrum disorder
Author(s) Kirkovski, MelissaORCID iD for Kirkovski, Melissa orcid.org/0000-0003-3395-8525
Enticott, Peter G.ORCID iD for Enticott, Peter G. orcid.org/0000-0002-6638-951X
Maller, Jerome J.
Rossell, Susan L.
Fitzgerald, Paul B.
Journal name Psychiatry research - neuroimaging
Volume number 233
Issue number 1
Start page 64
End page 72
Total pages 9
Publisher Elsevier
Place of publication Amsterdam, The Netherlands
Publication date 2015-07-30
ISSN 0925-4927
Keyword(s) Autism spectrum disorder
Diffusion tensor imaging
Magnetic resonance imaging
Tract-based spatial statistics
Summary Abnormalities within white matter (WM) have been identified in autism spectrum disorder (ASD). Although there is some support for greater neurobiological deficits among females with ASD, there is little research investigating sex differences in WM in ASD. We used diffusion tensor imaging (DTI) to investigate WM aberration in 25 adults with high-functioning ASD and 24 age-, sex- and IQ-matched controls. Tract-based spatial statistics (TBSS) was used to explore differences in WM in major tract bundles. The effects of biological sex were also investigated. TBSS revealed no differences in fractional anisotropy (FA), mean diffusivity (MD), radial diffusivity (RD), or axial diffusivity (AD) between groups. There were no effects of biological sex. We consider whether methodological differences between past studies have contributed to the highly heterogeneous findings in the literature. Finally, we suggest that, among a high-functioning sample of adults with ASD, differences in WM microstructure may not be related to clinical impairment.
Language eng
DOI 10.1016/j.pscychresns.2015.05.003
Field of Research 170101 Biological Psychology (Neuropsychology, Psychopharmacology, Physiological Psychology)
Socio Economic Objective 920410 Mental Health
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2015, Elsevier
Persistent URL http://hdl.handle.net/10536/DRO/DU:30073787

Document type: Journal Article
Collections: Faculty of Health
School of Psychology
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