Openly accessible

An adjunctive antidepressant nutraceutical combination in treating major depression: study protocol and clinical considerations

Sarris, Jerome, Stough, Con, Bousman, Chad, Murphy, Jenifer, Savage, Karen, Smith, Deidre, Menon, Ranjit, Chamoli, Suneel, Oliver, Georgina, Berk, Michael, Byrne, Gerard, Ng, Chee and Mischoulon, David 2015, An adjunctive antidepressant nutraceutical combination in treating major depression: study protocol and clinical considerations, Advances in integrative medicine, vol. 2, no. 1, pp. 49-56, doi: 10.1016/j.aimed.2015.02.001.

Attached Files
Name Description MIMEType Size Downloads
berk-adjunctiveantidepressant-2015.pdf Published version application/pdf 1.21MB 65

Title An adjunctive antidepressant nutraceutical combination in treating major depression: study protocol and clinical considerations
Author(s) Sarris, Jerome
Stough, Con
Bousman, Chad
Murphy, Jenifer
Savage, Karen
Smith, Deidre
Menon, Ranjit
Chamoli, Suneel
Oliver, Georgina
Berk, MichaelORCID iD for Berk, Michael orcid.org/0000-0002-5554-6946
Byrne, Gerard
Ng, Chee
Mischoulon, David
Journal name Advances in integrative medicine
Volume number 2
Issue number 1
Start page 49
End page 56
Total pages 7
Publisher Elsevier
Place of publication Amsterdam, The Netherlands
Publication date 2015-04
ISSN 2212-9588
2212-9596
Keyword(s) Antidepressant
Depression
Nutraceutical
Nutrient
Omega-3
Protocol
RCT
S-Adenosyl methionine
SAMe
Summary Current treatment for major depressive disorder (MDD), a prevalent and disabling mental illness, is inadequate, with two-thirds of people treated with first-line antidepressants not achieving remission. MDD is for many a chronic condition, often requiring multiple treatment attempts, thus development of additional interventions is urgently required. An emerging approach to improve non-response to antidepressants is the use of adjunctive nutraceuticals. The pathophysiology of MDD is considered to involve a range of abnormalities (monoamine impairment, neuro-endocrinological changes, reduced brain-derived neurotrophic factor, and cytokine alterations). By targeting an array of these key neurobiological pathways via specific nutraceuticals (S-adenosyl methionine; [SAMe], 5-HTP [active tryptophan], folinic acid [active folic acid], omega-3 fatty acids, and zinc), there is the potential to provide a more comprehensive therapeutic biological approach to treat depression. We are currently conducting a National Health and Medical Research Council funded study in Australia (APP1048222). The clinical trial is phase II/III, multi-site, 3-arm, 8-week, randomised, double-blind, placebo-controlled study using SAMe + folinic acid versus a combination nutraceutical (SAMe, 5-HTP, folinic acid, omega-3, and zinc) or matching placebo in 300 currently depressed participants with diagnosed MDD who are non-responsive to current antidepressants (ANZCTR, protocol number: 12613001300763). The results may provide evidence for a novel adjunctive neurobiological approach for treating depression.
Language eng
DOI 10.1016/j.aimed.2015.02.001
Field of Research 110319 Psychiatry (incl Psychotherapy)
Socio Economic Objective 920410 Mental Health
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2015, Elsevier
Free to Read? Yes
Use Rights Creative Commons Attribution Non-Commercial No-Derivatives licence
Persistent URL http://hdl.handle.net/10536/DRO/DU:30073811

Document type: Journal Article
Collections: Faculty of Health
School of Medicine
Open Access Collection
Connect to link resolver
 
Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved.

Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.

Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 8 times in TR Web of Science
Scopus Citation Count Cited 9 times in Scopus
Google Scholar Search Google Scholar
Access Statistics: 298 Abstract Views, 69 File Downloads  -  Detailed Statistics
Created: Fri, 12 Jun 2015, 16:56:30 EST

Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.