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Effects of persisting emotional impact from child abuse and norepinephrine transporter genetic variation on antidepressant efficacy in major depression: a pilot study

Singh, Ajeet Bhagat, Bousman, Chad A., Ng, Chee Hong, Byron, Keith and Berk, Michael 2015, Effects of persisting emotional impact from child abuse and norepinephrine transporter genetic variation on antidepressant efficacy in major depression: a pilot study, Clinical psychopharmacology and neuroscience, vol. 13, no. 1, pp. 53-61, doi: 10.9758/cpn.2015.13.1.53.

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Title Effects of persisting emotional impact from child abuse and norepinephrine transporter genetic variation on antidepressant efficacy in major depression: a pilot study
Author(s) Singh, Ajeet Bhagat
Bousman, Chad A.
Ng, Chee Hong
Byron, Keith
Berk, MichaelORCID iD for Berk, Michael orcid.org/0000-0002-5554-6946
Journal name Clinical psychopharmacology and neuroscience
Volume number 13
Issue number 1
Start page 53
End page 61
Total pages 9
Publisher Korean College of Neuropsychopharmacology
Place of publication Korea (South)
Publication date 2015
ISSN 1738-1088
2093-4327
Keyword(s) Abuse
Antidepressants
Child
Norepinephrine transporter
Remission
Science & Technology
Life Sciences & Biomedicine
Neurosciences
Pharmacology & Pharmacy
Neurosciences & Neurology
POSTTRAUMATIC-STRESS-DISORDER
SEROTONIN TRANSPORTER
SEXUAL ABUSE
MALTREATED CHILDREN
NEUROTRANSMITTER TRANSPORTERS
MATERNAL-CARE
LIFE STRESS
METAANALYSIS
PROMOTER
POLYMORPHISMS
Summary OBJECTIVE: Previous studies suggest child abuse and serotonergic polymorphism influence depression susceptibility and antidepressant efficacy. Polymorphisms of the norepinephrine transporter (NET) may also be involved. Research in the area is possibly clouded by under reporting of abuse in researcher trials. METHODS: Adults (n=51) with major depressive disorder has 8 weeks treatment with escitalopram or venlafaxine. Abuse history was obtained, the ongoing emotional impact of which was measured with the 15-item impact of event scale (IES-15). The 17-item Hamilton Depression Rating Scale (HDRS) was applied serially. Two NET polymorphisms (rs2242446 and rs5569) were assayed, blinded to HDRS ratings and abuse history. RESULTS: No subjects reporting abuse with high impact in adulthood (IES-15 ≥26, n=12) remitted; whereas 77% reporting low impact (IES-15 <26; n=26) remitted (p<0.001). Subjects reporting high impact abuse (n=12) had a 50-fold (95% confidence interval=4.85-514.6) greater odds of carrying rs2242446-TT genotype, but the small sample size leaves this finding vulnerable to type I error. CONCLUSIONS: The level of persisting impact of child abuse appears relevant to antidepressant efficacy, with susceptibility to such possibly being influence by NET rs2242446 polymorphism. Larger studies may be merited to expand on this pilot level finding given potential for biomarker utility.
Language eng
DOI 10.9758/cpn.2015.13.1.53
Field of Research 110319 Psychiatry (incl Psychotherapy)
Socio Economic Objective 920410 Mental Health
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2015, Korean College of Neuropsychopharmacology
Free to Read? Yes
Persistent URL http://hdl.handle.net/10536/DRO/DU:30073832

Document type: Journal Article
Collections: Faculty of Health
School of Medicine
Open Access Collection
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Created: Mon, 15 Jun 2015, 14:30:01 EST

Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.