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The many roads to mitochondrial dysfunction in neuroimmune and neuropsychiatric disorders

Morris, Gerwyn and Berk, Michael 2015, The many roads to mitochondrial dysfunction in neuroimmune and neuropsychiatric disorders, BMC medicine, vol. 13, pp. 1-25, doi: 10.1186/s12916-015-0310-y.

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Title The many roads to mitochondrial dysfunction in neuroimmune and neuropsychiatric disorders
Author(s) Morris, Gerwyn
Berk, MichaelORCID iD for Berk, Michael orcid.org/0000-0002-5554-6946
Journal name BMC medicine
Volume number 13
Article ID 68
Start page 1
End page 25
Total pages 25
Publisher BioMed Central
Place of publication London, Eng.
Publication date 2015
ISSN 1741-7015
Keyword(s) Autism
Bipolar disorder
Chronic fatigue syndrome
Cytokines
Depression
Immune dysfunction
Inflammatory
Mitochondrial dysfunction
Multiple sclerosis
Neurology
Nitric oxide
Oxidative stress
Parkinson's disease
Peroxynitrite
Psychiatry
Schizophrenia
Science & Technology
Life Sciences & Biomedicine
Medicine, General & Internal
General & Internal Medicine
CHRONIC-FATIGUE-SYNDROME
TUMOR-NECROSIS-FACTOR
MAJOR DEPRESSIVE DISORDER
CYTOCHROME-C-OXIDASE
MAGNETIC-RESONANCE-SPECTROSCOPY
REMITTING MULTIPLE-SCLEROSIS
AUTISM SPECTRUM DISORDERS
ELECTRON-TRANSPORT CHAIN
NITROSATIVE STRESS PATHWAYS
BLOOD MONONUCLEAR-CELLS
Summary BACKGROUND: Mitochondrial dysfunction and defects in oxidative metabolism are a characteristic feature of many chronic illnesses not currently classified as mitochondrial diseases. Examples of such illnesses include bipolar disorder, multiple sclerosis, Parkinson's disease, schizophrenia, depression, autism, and chronic fatigue syndrome.

DISCUSSION: While the majority of patients with multiple sclerosis appear to have widespread mitochondrial dysfunction and impaired ATP production, the findings in patients diagnosed with Parkinson's disease, autism, depression, bipolar disorder schizophrenia and chronic fatigue syndrome are less consistent, likely reflecting the fact that these diagnoses do not represent a disease with a unitary pathogenesis and pathophysiology. However, investigations have revealed the presence of chronic oxidative stress to be an almost invariant finding in study cohorts of patients afforded each diagnosis. This state is characterized by elevated reactive oxygen and nitrogen species and/or reduced levels of glutathione, and goes hand in hand with chronic systemic inflammation with elevated levels of pro-inflammatory cytokines.

SUMMARY: This paper details mechanisms by which elevated levels of reactive oxygen and nitrogen species together with elevated pro-inflammatory cytokines could conspire to pave a major road to the development of mitochondrial dysfunction and impaired oxidative metabolism seen in many patients diagnosed with these disorders.
Language eng
DOI 10.1186/s12916-015-0310-y
Field of Research 110319 Psychiatry (incl Psychotherapy)
Socio Economic Objective 920410 Mental Health
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2015, The Authors
Free to Read? Yes
Use Rights Creative Commons Attribution licence
Persistent URL http://hdl.handle.net/10536/DRO/DU:30073842

Document type: Journal Article
Collections: Faculty of Health
School of Medicine
Open Access Collection
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Created: Mon, 15 Jun 2015, 16:27:10 EST

Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.