Mitochondrial dysfunction in the pathophysiology of bipolar disorder: effects of pharmacotherapy

Callaly, Edward, Walder, Ken, Morris, Gerwyn, Maes, Michael, Debnath, Monojit and Berk, Michael 2015, Mitochondrial dysfunction in the pathophysiology of bipolar disorder: effects of pharmacotherapy, Mini-reviews in medicinal chemistry, vol. 15, no. 5, pp. 355-365.

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Title Mitochondrial dysfunction in the pathophysiology of bipolar disorder: effects of pharmacotherapy
Author(s) Callaly, Edward
Walder, KenORCID iD for Walder, Ken orcid.org/0000-0002-6758-4763
Morris, Gerwyn
Maes, Michael
Debnath, Monojit
Berk, MichaelORCID iD for Berk, Michael orcid.org/0000-0002-5554-6946
Journal name Mini-reviews in medicinal chemistry
Volume number 15
Issue number 5
Start page 355
End page 365
Total pages 11
Publisher Bentham Science Publishers
Place of publication Amsterdam, The Netherlands
Publication date 2015
ISSN 1875-5607
Keyword(s) Bipolar disorder
Mitochondria
Mood stabiliser
Neuroprogression
Oxidative stress
Science & Technology
Life Sciences & Biomedicine
Chemistry, Medicinal
Pharmacology & Pharmacy
TUMOR-NECROSIS-FACTOR
MAGNETIC-RESONANCE-SPECTROSCOPY
ELECTRON-TRANSPORT CHAIN
ANTERIOR CINGULATE CORTEX
PLACEBO-CONTROLLED TRIAL
CENTRAL-NERVOUS-SYSTEM
ENCEPHALOMYELITIS/CHRONIC FATIGUE SYNDROME
DORSOLATERAL PREFRONTAL CORTEX
SUBUNIT GENE NDUFV2
Summary Bipolar disorder is a common, chronic, and complex mental illness. Bipolar disorder is frequently comorbid with primary mitochondrial and metabolic disorders, and studies have implicated mitochondrial dysfunction in its pathophysiology. In the brains of people with bipolar disorder, high-energy phosphates are decreased, lactate is elevated and pH decreased, which together suggest a shift toward glycolysis for energy production. Furthermore, oxidative stress is increased, and calcium signalling dysregulated. Additionally there is downregulation of the expression of mitochondrial complexes, especially complex I. The therapeutic effects of some bipolar disorder drugs have recently been shown to be related to these mechanisms. In this review we will evaluate current research on the interactions between mitochondrial dysfunction and bipolar disorder pathology. We will then appraise the current literature describing the effects of bipolar disorder drugs on mitochondrial function, and discuss ramifications for future research.
Language eng
Field of Research 110319 Psychiatry (incl Psychotherapy)
Socio Economic Objective 920410 Mental Health
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2015, Bentham Science Publishers
Persistent URL http://hdl.handle.net/10536/DRO/DU:30073845

Document type: Journal Article
Collection: School of Medicine
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