Mitochondrial dysfunction in the pathophysiology of bipolar disorder: effects of pharmacotherapy Callaly, Edward, Walder, Ken, Morris, Gerwyn, Maes, Michael, Debnath, Monojit and Berk, Michael 2015, Mitochondrial dysfunction in the pathophysiology of bipolar disorder: effects of pharmacotherapy, Mini-reviews in medicinal chemistry, vol. 15, no. 5, pp. 355-365. Attached Files Name Description MIMEType Size Downloads Title Mitochondrial dysfunction in the pathophysiology of bipolar disorder: effects of pharmacotherapy Author(s) Callaly, Edward Walder, Ken orcid.org/0000-0002-6758-4763 Morris, Gerwyn Maes, Michael Debnath, Monojit Berk, Michael orcid.org/0000-0002-5554-6946 Journal name Mini-reviews in medicinal chemistry Volume number 15 Issue number 5 Start page 355 End page 365 Total pages 11 Publisher Bentham Science Publishers Place of publication Amsterdam, The Netherlands Publication date 2015 ISSN 1875-5607 Keyword(s) Bipolar disorder Mitochondria Mood stabiliser Neuroprogression Oxidative stress Science & Technology Life Sciences & Biomedicine Chemistry, Medicinal Pharmacology & Pharmacy TUMOR-NECROSIS-FACTOR MAGNETIC-RESONANCE-SPECTROSCOPY ELECTRON-TRANSPORT CHAIN ANTERIOR CINGULATE CORTEX PLACEBO-CONTROLLED TRIAL CENTRAL-NERVOUS-SYSTEM ENCEPHALOMYELITIS/CHRONIC FATIGUE SYNDROME DORSOLATERAL PREFRONTAL CORTEX SUBUNIT GENE NDUFV2 Summary Bipolar disorder is a common, chronic, and complex mental illness. Bipolar disorder is frequently comorbid with primary mitochondrial and metabolic disorders, and studies have implicated mitochondrial dysfunction in its pathophysiology. In the brains of people with bipolar disorder, high-energy phosphates are decreased, lactate is elevated and pH decreased, which together suggest a shift toward glycolysis for energy production. Furthermore, oxidative stress is increased, and calcium signalling dysregulated. Additionally there is downregulation of the expression of mitochondrial complexes, especially complex I. The therapeutic effects of some bipolar disorder drugs have recently been shown to be related to these mechanisms. In this review we will evaluate current research on the interactions between mitochondrial dysfunction and bipolar disorder pathology. We will then appraise the current literature describing the effects of bipolar disorder drugs on mitochondrial function, and discuss ramifications for future research. Language eng Field of Research 110319 Psychiatry (incl Psychotherapy) Socio Economic Objective 920410 Mental Health HERDC Research category C1 Refereed article in a scholarly journal Copyright notice ©2015, Bentham Science Publishers Persistent URL http://hdl.handle.net/10536/DRO/DU:30073845 Document type: Journal Article Collection: School of Medicine Related Links Link Description Author URL Go to link with your DU access privileges     Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved. Versions Version Filter Type Mon, 15 Jun 2015, 16:31:43 EST Tue, 16 Jun 2015, 05:02:08 EST Tue, 16 Jun 2015, 11:37:41 EST Thu, 18 Jun 2015, 12:58:34 EST Sat, 12 Sep 2015, 06:12:21 EST Thu, 19 Nov 2015, 15:24:48 EST Tue, 24 Nov 2015, 14:36:24 EST Mon, 19 Feb 2018, 19:19:14 EST Fri, 23 Feb 2018, 15:20:58 EST Fri, 23 Feb 2018, 15:21:42 EST Filtered Full Citation counts:   Cited 19 times in TR Web of Science Cited 19 times in Scopus Search Google Scholar Access Statistics: 295 Abstract Views, 9 File Downloads  -  Detailed Statistics Created: Mon, 15 Jun 2015, 16:31:43 EST

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