Mechanisms underlying neurocognitive dysfunctions in recurrent major depression Gałecki, Piotr, Talarowska, Monika, Anderson, George, Berk, Michael and Maes, Michael 2015, Mechanisms underlying neurocognitive dysfunctions in recurrent major depression, Medical Science Monitor, vol. 21, pp. 1535-1547, doi: 10.12659/MSM.893176. Attached Files Name Description MIMEType Size Downloads berk-mechanismsunderlying-2015.pdf Published version application/pdf 263.84KB 88 Title Mechanisms underlying neurocognitive dysfunctions in recurrent major depression Author(s) Gałecki, Piotr Talarowska, Monika Anderson, George Berk, Michael orcid.org/0000-0002-5554-6946 Maes, Michael Journal name Medical Science Monitor Volume number 21 Start page 1535 End page 1547 Total pages 13 Publisher Medical Science International Publishing Place of publication Warsaw, Poland Publication date 2015 ISSN 1643-3750 Summary Recent work shows that depression is intimately associated with changes in cognitive functioning, including memory, attention, verbal fluency, and other aspects of higher-order cognitive processing. Changes in cognitive functioning are more likely to occur when depressive episodes are recurrent and to abate to some degree during periods of remission. However, with accumulating frequency and duration of depressive episodes, cognitive deficits can become enduring, being evident even when mood improves. Such changes in cognitive functioning give depression links to mild cognitive impairment and thereby with neurodegenerative conditions, including Alzheimer's disease, Parkinson's disease, schizophrenia, and multiple sclerosis. Depression may then be conceptualized on a dimension of depression - mild cognitive impairment - dementia. The biological underpinnings of depression have substantial overlaps with those of neurodegenerative conditions, including reduced neurogenesis, increased apoptosis, reactive oxygen species, tryptophan catabolites, autoimmunity, and immune-inflammatory processes, as well as decreased antioxidant defenses. These evolving changes over the course of depressive episodes drive the association of depression with neurodegenerative conditions. As such, the changes in cognitive functioning in depression have important consequences for the treatment of depression and in reconceptualizing the role of depression in wider neuroprogressive conditions. Here we review the data on changes in cognitive functioning in recurrent major depression and their association with other central conditions. Language eng DOI 10.12659/MSM.893176 Field of Research 111714 Mental Health Socio Economic Objective 920410 Mental Health HERDC Research category C1 Refereed article in a scholarly journal Copyright notice ©2015, Medical Science Monitor Free to Read? Yes Use Rights Persistent URL http://hdl.handle.net/10536/DRO/DU:30073852 Document type: Journal Article Collections: Faculty of Health School of Medicine Open Access Collection Related Links Link Description Connect to published version Go to link with your DU access privileges   Author URL Go to link with your DU access privileges     Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved. Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au. Versions Version Filter Type Mon, 15 Jun 2015, 18:43:29 EST Tue, 16 Jun 2015, 05:02:42 EST Tue, 16 Jun 2015, 10:43:10 EST Tue, 16 Jun 2015, 10:48:40 EST Tue, 16 Jun 2015, 10:50:38 EST Thu, 18 Jun 2015, 12:58:59 EST Mon, 12 Oct 2015, 16:08:52 EST Wed, 14 Oct 2015, 14:27:31 EST Fri, 23 Oct 2015, 05:12:39 EST Wed, 18 Nov 2015, 12:40:46 EST Tue, 24 Nov 2015, 14:50:21 EST Fri, 26 Aug 2016, 15:54:54 EST Mon, 05 Sep 2016, 16:28:14 EST Wed, 07 Sep 2016, 09:31:31 EST Fri, 07 Sep 2018, 12:09:15 EST Filtered Full Citation counts:   Cited 0 times in TR Web of Science Cited 50 times in Scopus Search Google Scholar Access Statistics: 378 Abstract Views, 89 File Downloads  -  Detailed Statistics Created: Mon, 15 Jun 2015, 18:43:29 EST

Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.