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Age-related proteostasis and metabolic alterations in Caspase-2-deficient mice.

Wilson,CH, Shalini,S, Filipovska,A, Richman,TR, Davies,S, Martin,SD, McGee,SL, Puccini,J, Nikolic,A, Dorstyn,L and Kumar,S 2015, Age-related proteostasis and metabolic alterations in Caspase-2-deficient mice., Cell Death and Disease, vol. 6, pp. e1597, doi: 10.1038/cddis.2014.567.

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Title Age-related proteostasis and metabolic alterations in Caspase-2-deficient mice.
Author(s) Wilson,CH
Shalini,S
Filipovska,A
Richman,TR
Davies,S
Martin,SD
McGee,SL
Puccini,J
Nikolic,A
Dorstyn,L
Kumar,S
Journal name Cell Death and Disease
Volume number 6
Start page e1597
Publisher Nature Publishing Group
Place of publication England
Publication date 2015
ISSN 2041-4889
Keyword(s) Science & Technology
Life Sciences & Biomedicine
Cell Biology
SENESCENCE-ACCELERATED MICE
DNA-DAMAGE RESPONSE
MOUSE-LIVER
CALORIC RESTRICTION
GLUCOSE-PRODUCTION
OXIDATIVE STRESS
TUMOR-SUPPRESSOR
CASPASE-2
EXPRESSION
APOPTOSIS
Summary Ageing is a complex biological process for which underlying biochemical changes are still largely unknown. We performed comparative profiling of the cellular proteome and metabolome to understand the molecular basis of ageing in Caspase-2-deficient (Casp2(-/-)) mice that are a model of premature ageing in the absence of overt disease. Age-related changes were determined in the liver and serum of young (6-9 week) and aged (18-24 month) wild-type and Casp2(-/-) mice. We identified perturbed metabolic pathways, decreased levels of ribosomal and respiratory complex proteins and altered mitochondrial function that contribute to premature ageing in the Casp2(-/-) mice. We show that the metabolic profile changes in the young Casp2(-/-) mice resemble those found in aged wild-type mice. Intriguingly, aged Casp2(-/-) mice were found to have reduced blood glucose and improved glucose tolerance. These results demonstrate an important role for caspase-2 in regulating proteome and metabolome remodelling during ageing.
Language eng
DOI 10.1038/cddis.2014.567
Field of Research 110199 Medical Biochemistry and Metabolomics not elsewhere classified
Socio Economic Objective 929999 Health not elsewhere classified
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2015, Nature Publishing Group
Free to Read? Yes
Use Rights Creative Commons Attribution licence
Persistent URL http://hdl.handle.net/10536/DRO/DU:30073895

Document type: Journal Article
Collections: School of Medicine
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Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.