Reduced graphene oxide directed self-assembly of phospholipid monolayers in liquid and gel phases

Rui, Longfei, Liu, Jiaojiao, Li, Jingliang, Weng, Yuyan, Dou,Yujiang, Yuan, Bing, Yang, Kai and Ma,Yuqiang 2015, Reduced graphene oxide directed self-assembly of phospholipid monolayers in liquid and gel phases, Biochimica et biophysica acta, vol. 1848, no. 5, pp. 1203-1211, doi: 10.1016/j.bbamem.2015.02.018.

Attached Files
Name Description MIMEType Size Downloads

Title Reduced graphene oxide directed self-assembly of phospholipid monolayers in liquid and gel phases
Author(s) Rui, Longfei
Liu, Jiaojiao
Li, JingliangORCID iD for Li, Jingliang
Weng, Yuyan
Yuan, Bing
Yang, Kai
Journal name Biochimica et biophysica acta
Volume number 1848
Issue number 5
Start page 1203
End page 1211
Total pages 9
Publisher Elsevier
Place of publication Amsterdam, The Netherlands
Publication date 2015-05
ISSN 0006-3002
Keyword(s) phospholipid monolayer
reduced graphene oxide
Summary The response of cell membranes to the local physical environment significantly determines many biological processes and the practical applications of biomaterials. A better understanding of the dynamic assembly and environmental response of lipid membranes can help understand these processes and design novel nanomaterials for biomedical applications. The present work demonstrates the directed assembly of lipid monolayers, in both liquid and gel phases, on the surface of a monolayered reduced graphene oxide (rGO). The results from atomic force microscopy indicate that the hydrophobic aromatic plane and the defect holes due to reduction of GO sheets, along with the phase state and planar surface pressure of lipids, corporately determine the morphology and lateral structure of the assembled lipid monolayers. The DOPC molecules, in liquid phase, probably spread over the rGO surface with their tails associating closely with the hydrophobic aromatic plane, and accumulate to form circles of high area surrounding the defect holes on rGO sheets. However, the DPPC molecules, in gel phase, prefer to form a layer of continuous membrane covering the whole rGO sheet including defect holes. The strong association between rGO sheets and lipid tails further influences the melting behavior of lipids. This work reveals a dramatic effect of the local structure and surface property of rGO sheets on the substrate-directed assembly and subsequent phase behavior of the supported lipid membranes.
Language eng
DOI 10.1016/j.bbamem.2015.02.018
Field of Research 090301 Biomaterials
020405 Soft Condensed Matter
Socio Economic Objective 970109 Expanding Knowledge in Engineering
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2015, Elsevier
Persistent URL

Document type: Journal Article
Collection: Institute for Frontier Materials
Connect to link resolver
Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved.

Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 9 times in TR Web of Science
Scopus Citation Count Cited 9 times in Scopus
Google Scholar Search Google Scholar
Access Statistics: 204 Abstract Views, 2 File Downloads  -  Detailed Statistics
Created: Tue, 07 Jul 2015, 15:24:33 EST

Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact