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Specific role of dietary fat in modifying cardiovascular and locomotor activity 24-h rhythms

Barzel, Benjamin, Lim, Kyungjoon, Burke, Sandra L., Armitage, James A. and Head, Geoffrey A. 2015, Specific role of dietary fat in modifying cardiovascular and locomotor activity 24-h rhythms, Chronobiology international, vol. 32, no. 5, pp. 668-676, doi: 10.3109/07420528.2015.1032414.

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Title Specific role of dietary fat in modifying cardiovascular and locomotor activity 24-h rhythms
Author(s) Barzel, Benjamin
Lim, Kyungjoon
Burke, Sandra L.
Armitage, James A.
Head, Geoffrey A.
Journal name Chronobiology international
Volume number 32
Issue number 5
Start page 668
End page 676
Total pages 9
Publisher Taylor & Francis
Place of publication Oxford, Eng.
Publication date 2015
ISSN 0742-0528
1525-6073
Keyword(s) 24-h rhythm
blood pressure
heart rate
high-fat diet
obesity
rabbits
Summary Meal-fed conscious rabbits normally exhibit postprandial elevation in blood pressure, heart rate (HR) and locomotor activity, which is abolished by consumption of a high-fat diet (HFD). Here, we assessed whether the cardiovascular changes are attributable to the increased caloric intake due to greater fat content or to hyperphagia. Rabbits were meal-fed during the baseline period then maintained on either an ad libitum normal fat diet (NFD) or ad libitum HFD for 2 weeks. Blood pressure, HR and locomotor activity were measured daily by radio-telemetry alongside food intake and body weight. Caloric intake in rabbits given a NFD ad libitum rose 50% from baseline but there were no changes in cardiovascular parameters. By contrast, HR increased by 10% on the first day of the ad libitum HFD (p<0.001) prior to any change in body weight while blood pressure increased 7% after 4d (p<0.01) and remained elevated. Baseline 24-h patterns of blood pressure and HR were closely associated with mealtime, characterised by afternoon peaks and morning troughs. When the NFD was changed from meal-fed to ad libitum, blood pressure and HR did not change but afternoon activity levels decreased (p<0.05). By contrast, after 13d ad libitum HFD, morning HR, blood pressure and activity increased by 20%, 8% and 71%, respectively. Increased caloric intake specifically from fat, but not as a result of hyperphagia, appears to directly modulate cardiovascular homeostasis and circadian patterns, independent of white adipose tissue accumulation.
Language eng
DOI 10.3109/07420528.2015.1032414
Field of Research 110299 Cardiovascular Medicine and Haematology not elsewhere classified
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2015, Informa Healthcare USA
Persistent URL http://hdl.handle.net/10536/DRO/DU:30074172

Document type: Journal Article
Collection: School of Medicine
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Created: Thu, 09 Jul 2015, 13:20:47 EST

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