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Effect of retinal image defocus on the thickness of the human choroid

Chiang, Samuel T-H., Phillips, John R. and Backhouse, Simon 2015, Effect of retinal image defocus on the thickness of the human choroid, Ophthalmic and physiological optics, vol. 35, no. 4, pp. 405-413, doi: 10.1111/opo.12218.

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Title Effect of retinal image defocus on the thickness of the human choroid
Author(s) Chiang, Samuel T-H.
Phillips, John R.
Backhouse, SimonORCID iD for Backhouse, Simon orcid.org/0000-0002-5988-1469
Journal name Ophthalmic and physiological optics
Volume number 35
Issue number 4
Start page 405
End page 413
Total pages 9
Publisher Wiley
Place of publication Chichester, Eng.
Publication date 2015
ISSN 1475-1313
Keyword(s) choroid
emmetropia
eye
hyperopia
myopia
optical coherence tomography
Science & Technology
Life Sciences & Biomedicine
Ophthalmology
DIFFUSE LUMINANCE FLICKER
FORM-DEPRIVATION MYOPIA
HEAD BLOOD-FLOW
AXIAL LENGTH
INTRAOCULAR-PRESSURE
LENS COMPENSATION
DIURNAL-VARIATION
REFRACTIVE STATE
CONTACT-LENSES
Summary PURPOSE: To describe the time-course and amplitude of changes to sub-foveal choroidal thickness (SFCT) induced by imposed hyperopic and myopic retinal defocus and to compare the responses in emmetropic and myopic subjects. METHODS: Twelve East Asian subjects (age: 18-34 years; six were emmetropic and six had myopia between -2.00 and -5.00 dioptres (D)) viewed a distant target (video movie at 6 m) for 60 min on two separate occasions while optical coherence tomography (OCT) images of the choroid were taken in both eyes every 5 min to monitor SFCT. On each occasion, one eye was optimally corrected for distance with a contact lens while the other eye wore a contact lens imposing either 2.00 D hyperopic or 2.00 D myopic retinal defocus. RESULTS: Baseline SFCT in myopic eyes (mean ± S.D.): 256 ± 42 μm was significantly less than in emmetropic eyes (423 ± 62 μm; p < 0.01) and was correlated with magnitude of myopia (-39 μm per dioptre of myopia, R(2) = 0.67: p < 0.01). Repeated measures anova (General Linear Model) analysis revealed that in both subject groups, 2.00 D of myopic defocus caused a rapid increase in SFCT in the defocussed eye (significant by 10 min, increasing to approximately 20 μm within 60 min: p < 0.01), with little change in the control eye. In contrast, 2.00 D of hyperopic defocus caused a decrease in SFCT in the experimental eye (significant by 20-35 min. SFCT decreased by approximately 20 μm within 60 min: p < 0.01) with little change in the control eye. CONCLUSIONS: Small but significant changes in SFCT (5-8%) were caused by retinal defocus. SFCT increased within 10 min of exposure to 2.00 D of monocular myopic defocus, but decreased more slowly in response to 2.00 D of monocular hyperopic defocus. In our relatively small sample we could detect no difference in the magnitude of changes to SFCT caused by defocus in myopic eyes compared to emmetropic eyes.
Language eng
DOI 10.1111/opo.12218
Field of Research 111399 Ophthalmology and Optometry not elsewhere classified
Socio Economic Objective 929999 Health not elsewhere classified
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2015, Wiley
Persistent URL http://hdl.handle.net/10536/DRO/DU:30074225

Document type: Journal Article
Collection: School of Medicine
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