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Self-assembled peptide nanostructures for the fabrication of cell scaffolds

Li, Rui, Rodriguez, Alexandra, Nisbet, David R., Barrow, Colin J. and Williams, Richard J. 2015, Self-assembled peptide nanostructures for the fabrication of cell scaffolds. In Castillo-Leon, Jaime and Svendsen, Winnie E. (ed), Micro and nanofabrication using self-assembled biological nanostructures, Elsevier, Amsterdam, The Netherlands, pp.33-61, doi: 10.1016/B978-0-323-29642-7.00003-5.

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Title Self-assembled peptide nanostructures for the fabrication of cell scaffolds
Author(s) Li, Rui
Rodriguez, Alexandra
Nisbet, David R.
Barrow, Colin J.ORCID iD for Barrow, Colin J. orcid.org/0000-0002-2153-7267
Williams, Richard J.
Title of book Micro and nanofabrication using self-assembled biological nanostructures
Editor(s) Castillo-Leon, Jaime
Svendsen, Winnie E.
Publication date 2015
Chapter number 3
Total chapters 5
Start page 33
End page 61
Total pages 29
Publisher Elsevier
Place of Publication Amsterdam, The Netherlands
Keyword(s) Science & Technology
Life Sciences & Biomedicine
Technology
Biotechnology & Applied Microbiology
Engineering, Biomedical
Nanoscience & Nanotechnology
Engineering
Science & Technology - Other Topics
OSTEOBLAST-ADHESIVE PEPTIDES
MESENCHYMAL STEM-CELLS
DESIGNED PROTEIN FIBER
IN-VITRO
AMPHIPHILE NANOFIBERS
EXTRACELLULAR-MATRIX
COMPLEMENTARY OLIGOPEPTIDE
NEURITE OUTGROWTH
HYDROGELS
CULTURE
Summary The fabrication of artificial scaffolds that effectively mimic the host environment of the cell have exciting potential for the treatment of many diseases in regenerative medicine. In particular, appropriately designed scaffolds have the capacity to support, replace, and mediate the transplantation of therapeutic cells in order to regenerate damaged or diseased tissues. To achieve these goals for regeneration, the engineering of an environment structurally similar to the native extracellular matrix (ECM) is necessary in order to closely match the chemical and physical conditions found within the extracellular niche. Recently, self-assembled peptide (SAP) hydrogels have shown great potential for such biological applications due to their inherent biocompatibility, propensity to form higher order structures, rich chemical functionality and ease of synthesis. Importantly, it is possible to control the organization and properties of the target materials as the chemical structure is determined by amino acid sequence. Here, the development of SAP hydrogels as functional cell scaffolds and useful tools in tissue engineering is reviewed.
ISBN 9780323296427
Language eng
DOI 10.1016/B978-0-323-29642-7.00003-5
Field of Research 030302 Nanochemistry and Supramolecular Chemistry
Socio Economic Objective 970103 Expanding Knowledge in the Chemical Sciences
HERDC Research category B1 Book chapter
ERA Research output type B Book chapter
Copyright notice ©2015, Elsevier
Persistent URL http://hdl.handle.net/10536/DRO/DU:30074236

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