You are not logged in.
Openly accessible

Effects of long-term head-down-tilt bed rest and different training regimes on the coagulation system of healthy men

Haider, Thomas, Gunga, Hanns-Christian, Matteucci-Gothe, Raffaella, Sottara, Elke, Griesmacher, Andrea, Belavý, Daniel L., Felsenberg, Dieter, Werner, Andreas and Schobersberger, Wolfgang 2013, Effects of long-term head-down-tilt bed rest and different training regimes on the coagulation system of healthy men, Physiological reports, vol. 1, no. 6, Article Number : e00135, pp. 1-13, doi: 10.1002/phy2.135.

Attached Files
Name Description MIMEType Size Downloads
belavy-effectsoflong-2013.pdf Published version application/pdf 2.98MB 10

Title Effects of long-term head-down-tilt bed rest and different training regimes on the coagulation system of healthy men
Author(s) Haider, Thomas
Gunga, Hanns-Christian
Matteucci-Gothe, Raffaella
Sottara, Elke
Griesmacher, Andrea
Belavý, Daniel L.ORCID iD for Belavý, Daniel L. orcid.org/0000-0002-9307-832X
Felsenberg, Dieter
Werner, Andreas
Schobersberger, Wolfgang
Journal name Physiological reports
Volume number 1
Issue number 6
Season Article Number : e00135
Start page 1
End page 13
Total pages 13
Publisher American Physiological Society
Place of publication Bethesda, Md.
Publication date 2013-11
ISSN 2051-817X
Keyword(s) Hemostasis
head-down tilt
immobilization
resistance training
thromboelastography
Summary Immobility plus preexisting chronic disease or acute trauma can activate the coagulation system, thus increasing the risk for thromboembolic events. The effects of long-term bed-rest immobility and microgravity on the coagulation system of healthy persons (e.g., during crewed Mars missions) have not yet been studied. The main objective of the second Berlin BedRest Study (BBR2-2) "Coagulation Part" was to investigate adaptations of the hemostatic system during long-term bed rest (60 days) under simulated microgravity (6° head-down-tilt [6°HDT]) and after mobilization in three different volunteer groups (randomly assigned to CTR= inactive control group; RE= resistive exercise only group; and RVE= resistive exercise with whole-body vibration group). In 24 males (aged 21-45 years), before, during, and after long-term bed rest, key parameters of coagulation were measured from venous blood samples: D-dimer (DD), thrombin-antithrombin III complex (TAT), and prothrombin fragment F1 + 2 (PT-F1 + 2). Additionally, modified rotational thrombelastometry (ROTEM (®) ) analysis was performed. Times of exploratory analyses were as follows: baseline data collection 2 days before bed rest (BDC-2); eight different days of 6°HDT bed rest (HDT1-HDT60), and two different days after reambulation (R + 3 and R + 6). We found significant changes in DD, TAT, and PT-F1 + 2 over the total time course, but no consistent effect of physical interventions (RE, RVE) on these parameters. Notably, no parameter reached levels indicative of intravascular thrombin formation. All ROTEM® parameters remained within the normal range and no pathological traces were found. Sixty days of 6°HDT bed rest are not associated with pronounced activation of the coagulation system indicative of intravascular thrombus formation in healthy volunteers independent of the training type during the bed rest.
Language eng
DOI 10.1002/phy2.135
Field of Research 110699 Human Movement and Sports Science not elsewhere classified
Socio Economic Objective 920299 Health and Support Services not elsewhere classified
HERDC Research category C1.1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2013, The Authors
Persistent URL http://hdl.handle.net/10536/DRO/DU:30074243

Document type: Journal Article
Collections: School of Exercise and Nutrition Sciences
Open Access Collection
Connect to link resolver
 
Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved.

Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.

Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 0 times in TR Web of Science
Scopus Citation Count Cited 8 times in Scopus
Google Scholar Search Google Scholar
Access Statistics: 96 Abstract Views, 11 File Downloads  -  Detailed Statistics
Created: Thu, 09 Jul 2015, 13:54:01 EST

Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.