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Sensitivity of temporal heart rate variability in Poincaré plot to changes in parasympathetic nervous system activity

Karmakar, Chandan K., Khandoker, Ahsan H., Voss, Andreas and Palaniswami, Marimuthu 2011, Sensitivity of temporal heart rate variability in Poincaré plot to changes in parasympathetic nervous system activity, BioMedical engineering online, vol. 10, pp. 1-14, doi: 10.1186/1475-925X-10-17.

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Title Sensitivity of temporal heart rate variability in Poincaré plot to changes in parasympathetic nervous system activity
Author(s) Karmakar, Chandan K.ORCID iD for Karmakar, Chandan K. orcid.org/0000-0003-1814-0856
Khandoker, Ahsan H.
Voss, Andreas
Palaniswami, Marimuthu
Journal name BioMedical engineering online
Volume number 10
Article ID 17
Start page 1
End page 14
Total pages 14
Publisher BioMed Central
Place of publication London, Eng.
Publication date 2011
ISSN 1475-925X
Keyword(s) Adult
Computer Graphics
Heart Rate
Humans
Parasympathetic Nervous System
Statistics as Topic
Time Factors
Young Adult
Summary Background
A novel descriptor (Complex Correlation Measure (CCM)) for measuring the variability in the temporal structure of Poincaré plot has been developed to characterize or distinguish between Poincaré plots with similar shapes.

Methods
This study was designed to assess the changes in temporal structure of the Poincaré plot using CCM during atropine infusion, 70° head-up tilt and scopolamine administration in healthy human subjects. CCM quantifies the point-to-point variation of the signal rather than gross description of the Poincaré plot. The physiological relevance of CCM was demonstrated by comparing the changes in CCM values with autonomic perturbation during all phases of the experiment. The sensitivities of short term variability (SD 1), long term variability (SD 2) and variability in temporal structure (CCM) were analyzed by changing the temporal structure by shuffling the sequences of points of the Poincaré plot. Surrogate analysis was used to show CCM as a measure of changes in temporal structure rather than random noise and sensitivity of CCM with changes in parasympathetic activity.

Results
CCM was found to be most sensitive to changes in temporal structure of the Poincaré plot as compared to SD 1 and SD 2. The values of all descriptors decreased with decrease in parasympathetic activity during atropine infusion and 70° head-up tilt phase. In contrast, values of all descriptors increased with increase in parasympathetic activity during scopolamine administration.

Conclusions
The concordant reduction and enhancement in CCM values with parasympathetic activity indicates that the temporal variability of Poincaré plot is modulated by the parasympathetic activity which correlates with changes in CCM values. CCM is more sensitive than SD 1 and SD 2 to changes of parasympathetic activity.
Language eng
DOI 10.1186/1475-925X-10-17
Field of Research 090609 Signal Processing
090304 Medical Devices
HERDC Research category C1.1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2011, Karmakar et al
Free to Read? Yes
Use Rights Creative Commons Attribution licence
Persistent URL http://hdl.handle.net/10536/DRO/DU:30074271

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Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.