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Development of fluorescent and class selective HDAC Inhibitors

Fleming, Cassandra 2015, Development of fluorescent and class selective HDAC Inhibitors, Ph.D. thesis, School of Life and Environmental Sciences, Deakin University.

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Title Development of fluorescent and class selective HDAC Inhibitors
Author Fleming, Cassandra
Institution Deakin University
School School of Life and Environmental Sciences
Faculty Faculty of Science, Engineering and Built Environment
Degree type Research doctorate
Degree name Ph.D.
Thesis advisor Pfeffer, FrederickORCID iD for Pfeffer, Frederick orcid.org/0000-0002-5441-6437
Date submitted 2015-02
Keyword(s) histone deacetylase (HDAC) enzymes
cancer therapy
fluorescent inhibitors
cellular imaging
Summary  The inhibition of HDAC enzymes has proven beneficial for the treatment of a variety of diseases including cancer. This thesis details the development of class selective and fluorescent HDAC inhibitors for cellular imaging. Increased HDAC and anticancer activities were observed, and the fluorescent inhibitors were readily visualised in live cells.
Language eng
Field of Research 030503 Organic Chemical Synthesis
Socio Economic Objective 860803 Human Pharmaceutical Treatments (e.g. Antibiotics)
Description of original xxiii, 291 pages : illustrations, tables
Copyright notice ┬ęThe author
Persistent URL http://hdl.handle.net/10536/DRO/DU:30074274

Document type: Thesis
Collection: Higher degree theses (full text)
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Created: Fri, 10 Jul 2015, 14:13:13 EST by Kate Percival

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