The inhibition of HDAC enzymes has proven beneficial for the treatment of a variety of diseases including cancer. This thesis details the development of class selective and fluorescent HDAC inhibitors for cellular imaging. Increased HDAC and anticancer activities were observed, and the fluorescent inhibitors were readily visualised in live cells.
Field of Research
030503 Organic Chemical Synthesis
Socio Economic Objective
860803 Human Pharmaceutical Treatments (e.g. Antibiotics)
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