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Recombinant influenza viruses as a vaccine vector for HIV

Shallal, Mohammed Jasim Mohammed 2015, Recombinant influenza viruses as a vaccine vector for HIV, PhD thesis, School of Medicine, Deakin University.

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Title Recombinant influenza viruses as a vaccine vector for HIV
Author Shallal, Mohammed Jasim Mohammed
Institution Deakin University
School School of Medicine
Faculty Faculty of Health
Degree type Research doctorate
Degree name PhD
Thesis advisor John StambasORCID iD for John Stambas orcid.org/0000-0002-5690-2551
Ward Alister C.ORCID iD for Ward Alister C. orcid.org/0000-0001-7945-7975
Bean, Andrew
Date submitted 2015-03
Keyword(s) human immunodeficiency virus (HIV)
acquired immunodeficiency syndrome (AIDS)
vaccines
influenza viruses
Summary  Live recombinant influenza viruses were successfully used as HIV vaccine vectors in a mouse model. Following intranasal prime-boost vaccination, HIV-specific CD8+ T cell responses were detected in the spleen, broncho-alveolar lavage, mediastinal and inguinal lymph nodes. HIV+α4β7+ CD8+ T cells contributed to protection in pseudo-challenge experiments using recombinant vaccinia virus expressing HIV antigens. This research highlights the importance of mucosal CD8+ T cells in viral immunity and emphasizes the need for additional studies to provide key insights to underpin future vaccine development.
Language eng
Field of Research 110702 Applied Immunology (incl Antibody Engineering, Xenotransplantation and T-cell Therapies)
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
Description of original xvii, 217 pages : illustrations, tables, graphs
Dewey Decimal Classification 615.372
Copyright notice ┬ęThe Author. All Rights Reserved
Free to Read? Yes
Persistent URL http://hdl.handle.net/10536/DRO/DU:30074314

Document type: Thesis
Collections: Higher degree theses (full text)
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Created: Fri, 10 Jul 2015, 15:18:41 EST by Kate Percival

Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.