Fructose-1, 6-diphosphate (FDP) as a novel antidote for yellow oleander-induced cardiac toxicity: a randomized controlled double blind study Gawarammana, Indika, Mohamed, Fahim, Bowe, Steven J., Rathnathilake, Ashoka, Narangoda, Shantha K., Azher, Shifa, Dawson, Andrew H. and Buckley, Nick A. 2010, Fructose-1, 6-diphosphate (FDP) as a novel antidote for yellow oleander-induced cardiac toxicity: a randomized controlled double blind study, BMC emergency medicine, vol. 10, Article Number : 15, pp. 1-6, doi: 10.1186/1471-227X-10-15. Attached Files Name Description MIMEType Size Downloads bowe-fructose16-2010.pdf Published version application/pdf 1.53MB 72 Title Fructose-1, 6-diphosphate (FDP) as a novel antidote for yellow oleander-induced cardiac toxicity: a randomized controlled double blind study Author(s) Gawarammana, Indika Mohamed, Fahim Bowe, Steven J. orcid.org/0000-0003-3813-842X Rathnathilake, Ashoka Narangoda, Shantha K. Azher, Shifa Dawson, Andrew H. Buckley, Nick A. Journal name BMC emergency medicine Volume number 10 Season Article Number : 15 Start page 1 End page 6 Total pages 6 Publisher BioMed Central Place of publication London, Eng. Publication date 2010 ISSN 1471-227X Summary BACKGROUND: Cardiac toxicity due to ingestion of oleander plant seeds in Sri Lanka and some other South Asian countries is very common. At present symptomatic oleander seed poisoning carries a mortality of 10% in Sri Lanka and treatment of yellow oleander poisoning is limited to gastric decontamination and atropine administration. The only proven effective antidote is digoxin antibodies but these are not available for routine use because of the high cost. The main objective of this study is to investigate the effectiveness of a new and inexpensive antidote for patients with life threatening arrhythmias due oleander poisoning. METHOD/DESIGN: We set up a randomised double blind clinical trial to assess the effectiveness of Fructose 1, 6 diphosphate (FDP) in acute yellow oleander poisoning patients admitted to the adult medical wards of a tertiary hospital in Sri Lanka. Patients will be initially resuscitated following the national guidelines and eligible patients will be randomised to receive either FDP or an equal amount of normal saline. The primary outcome measure for this study is the sustained reversion to sinus rhythm with a heart rate greater than 50/min within 2 hours of completion of FDP/placebo bolus. Secondary outcomes include death, reversal of hyperkalaemia on the 6, 12, 18 and 24 hour samples and maintenance of sinus rhythm on the holter monitor. Analysis will be on intention-to-treat. DISCUSSION: This trial will provide information on the effectiveness of FDP in yellow oleander poisoning. If FDP is effective in cardiac glycoside toxicity, it would provide substantial benefit to the patients in rural Asia. The drug is inexpensive and thus could be made available at primary care hospitals if proven to be effective. TRIAL REGISTRATION: Current Controlled trial ISRCTN71018309. Language eng DOI 10.1186/1471-227X-10-15 Field of Research 110399 Clinical Sciences not elsewhere classified Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences HERDC Research category C1.1 Refereed article in a scholarly journal ERA Research output type C Journal article Copyright notice ©2010, The Authors Free to Read? Yes Persistent URL http://hdl.handle.net/10536/DRO/DU:30074320 Document type: Journal Article Collections: Faculty of Health Open Access Collection Related Links Link Description Connect to published version Go to link with your DU access privileges     Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved. Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au. Versions Version Filter Type Fri, 10 Jul 2015, 22:07:29 EST Sat, 11 Jul 2015, 05:03:11 EST Mon, 13 Jul 2015, 08:40:31 EST Mon, 13 Jul 2015, 08:49:49 EST Tue, 19 Jan 2016, 05:23:15 EST Fri, 29 Jan 2016, 14:47:56 EST Fri, 29 Jan 2016, 14:52:50 EST Fri, 29 Jan 2016, 14:53:57 EST Fri, 05 Feb 2016, 10:41:41 EST Wed, 10 Feb 2016, 08:25:22 EST Wed, 06 Dec 2017, 06:15:41 EST Fri, 07 Sep 2018, 17:35:14 EST Sat, 29 Aug 2020, 02:31:34 EST Filtered Full Citation counts:   Cited 12 times in TR Web of Science Cited 14 times in Scopus Search Google Scholar Access Statistics: 364 Abstract Views, 75 File Downloads  -  Detailed Statistics Created: Fri, 10 Jul 2015, 22:07:29 EST

Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.