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Evolution of optogenetic microdevices

Kale, Rajas P., Kouzani, Abbas Z., Walder, Ken, Berk, Michael and Tye, Susannah J. 2015, Evolution of optogenetic microdevices, Neurophotonics, vol. 2, no. 3, Article no: 031206, pp. 1-11, doi: 10.1117/1.NPh.2.3.031206.

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Title Evolution of optogenetic microdevices
Author(s) Kale, Rajas P.
Kouzani, Abbas Z.ORCID iD for Kouzani, Abbas Z. orcid.org/0000-0002-6292-1214
Walder, Ken
Berk, MichaelORCID iD for Berk, Michael orcid.org/0000-0002-5554-6946
Tye, Susannah J.
Journal name Neurophotonics
Volume number 2
Issue number 3
Season Article no: 031206
Start page 1
End page 11
Total pages 11
Publisher Society of Photo-Optical Instrumentation Engineers
Place of publication Bellingham, W.A.
Publication date 2015
ISSN 2329-423X
2329-4248
Keyword(s) behavioral tests
fiber coupling
neurology
optogenetics
portable microdevices
psychiatry
tethering
Summary Implementation of optogenetic techniques is a recent addition to the neuroscientists' preclinical research arsenal, helping to expose the intricate connectivity of the brain and allowing for on-demand direct modulation of specific neural pathways. Developing an optogenetic system requires thorough investigation of the optogenetic technique and of previously fabricated devices, which this review accommodates. Many experiments utilize bench-top systems that are bulky, expensive, and necessitate tethering to the animal. However, these bench-top systems can make use of power-demanding technologies, such as concurrent electrical recording. Newer portable microdevices and implantable systems carried by freely moving animals are being fabricated that take advantage of wireless energy harvesting to power a system and allow for natural movements that are vital for behavioral testing and analysis. An investigation of the evolution of tethered, portable, and implantable optogenetic microdevices is presented, and an analysis of benefits and detriments of each system, including optical power output, device dimensions, electrode width, and weight is given. Opsins, light sources, and optical fiber coupling are also discussed to optimize device parameters and maximize efficiency from the light source to the fiber, respectively. These attributes are important considerations when designing and developing improved optogenetic microdevices.
Language eng
DOI 10.1117/1.NPh.2.3.031206
Field of Research 090304 Medical Devices
Socio Economic Objective 861502 Medical Instruments
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2015, Society of Photo-Optical Instrumentation Engineers
Persistent URL http://hdl.handle.net/10536/DRO/DU:30074630

Document type: Journal Article
Collections: School of Medicine
School of Engineering
Open Access Collection
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Created: Wed, 22 Jul 2015, 15:52:05 EST

Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.