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Short communication: bovine-derived proteins activate STAT3 in human skeletal muscle in vitro

Caldow, M. K., Digby, M. R. and Cameron-Smith, D. 2015, Short communication: bovine-derived proteins activate STAT3 in human skeletal muscle in vitro, Journal of dairy science, vol. 98, no. 5, pp. 3016-3019, doi: 10.3168/jds.2014-9035.

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Title Short communication: bovine-derived proteins activate STAT3 in human skeletal muscle in vitro
Author(s) Caldow, M. K.
Digby, M. R.
Cameron-Smith, D.
Journal name Journal of dairy science
Volume number 98
Issue number 5
Start page 3016
End page 3019
Total pages 4
Publisher Elsevier
Place of publication Amsterdam, The Netherlands
Publication date 2015-05
ISSN 0022-0302
1525-3198
Keyword(s) Bovine protein
Cytokine
Growth factor
Skeletal muscle
STAT3
Summary Bovine milk contains biologically active peptides that may modulate growth and development within humans. In this study, targeted bovine-derived proteins were evaluated for their effects on signal transducer and activator of transcription-3 (STAT3) phosphorylation in human skeletal muscle cells. Following an acute exposure, bovine-derived acidic fibroblast growth factor-1 (FGF) and leukemia inhibitory factor (LIF) activated STAT3 in differentiating myotubes. Chronic exposure to FGF and LIF during the proliferative phase reduced myoblast proliferation and elevated MyoD and creatine kinase (CKM) mRNA expression without altering apoptotic genes. In mature myotubes, neither FGF nor LIF elicited any action. Together, these data indicate that a reduction in proliferation in the presence of bovine-derived FGF or LIF may stimulate early maturation of myoblasts.
Language eng
DOI 10.3168/jds.2014-9035
Field of Research 110699 Human Movement and Sports Science not elsewhere classified
Socio Economic Objective 929999 Health not elsewhere classified
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2015, American Dairy Science Association
Persistent URL http://hdl.handle.net/10536/DRO/DU:30074673

Document type: Journal Article
Collection: School of Exercise and Nutrition Sciences
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