The effects of anodal-tDCS on cross-limb transfer in older adults

Goodwill, Alicia M., Daly, Robin M. and Kidgell, Dawson J. 2015, The effects of anodal-tDCS on cross-limb transfer in older adults, Clinical neurophysiology, vol. 126, no. 11, pp. 2189-2197, doi: 10.1016/j.clinph.2015.01.006.

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Title The effects of anodal-tDCS on cross-limb transfer in older adults
Author(s) Goodwill, Alicia M.
Daly, Robin M.ORCID iD for Daly, Robin M.
Kidgell, Dawson J.
Journal name Clinical neurophysiology
Volume number 126
Issue number 11
Start page 2189
End page 2197
Total pages 9
Publisher Elsevier
Place of publication Amsterdam, The Netherlands
Publication date 2015-11
ISSN 1872-8952
Keyword(s) Cortical plasticity
Cross-limb transfer
Intracortical inhibition
Ipsilateral motor cortex
Motor practice
Summary OBJECTIVE: Age-related neurodegeneration may interfere with the ability to respond to cross-limb transfer, whereby bilateral performance improvements accompany unilateral practice. We investigated whether transcranial direct current stimulation (tDCS) would facilitate this phenomena in older adults. METHODS: 12 young and 12 older adults underwent unilateral visuomotor tracking (VT), with anodal or sham-tDCS over the ipsilateral motor cortex. Transcranial magnetic stimulation (TMS) assessed motor evoked potentials (MEPs) and short interval intracortical inhibition (SICI). Performance was quantified through a VT error. Variables were assessed bilaterally at baseline and post-intervention. RESULTS: The trained limb improved performance, facilitated MEPs and released SICI in both age groups. In the untrained limb, VT improved in young for both sham and anodal-tDCS conditions, but only following anodal-tDCS for the older adults. MEPs increased in all conditions, except the older adult's receiving sham. SICI was released in both tDCS conditions for young and old. CONCLUSION: Following a VT task, older adults still display use-dependent plasticity. Although no significant age-related differences between the outcome measures, older adults exhibited significant cross-limb transfer of performance following anodal-tDCS, which was otherwise absent following motor practice alone. SIGNIFICANCE: These findings provide clinical implications for conditions restricting the use of one limb, such as stroke.
Language eng
DOI 10.1016/j.clinph.2015.01.006
Field of Research 110699 Human Movement and Sports Science not elsewhere classified
Socio Economic Objective 920502 Health Related to Ageing
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2015, Elsevier
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