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The effects of anodal-tDCS on cross-limb transfer in older adults

Goodwill, Alicia M., Daly, Robin M. and Kidgell, Dawson J. 2015, The effects of anodal-tDCS on cross-limb transfer in older adults, Clinical neurophysiology, vol. 126, no. 11, pp. 2189-2197, doi: 10.1016/j.clinph.2015.01.006.

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Title The effects of anodal-tDCS on cross-limb transfer in older adults
Author(s) Goodwill, Alicia M.
Daly, Robin M.ORCID iD for Daly, Robin M. orcid.org/0000-0002-9897-1598
Kidgell, Dawson J.
Journal name Clinical neurophysiology
Volume number 126
Issue number 11
Start page 2189
End page 2197
Total pages 9
Publisher Elsevier
Place of publication Amsterdam, The Netherlands
Publication date 2015-11
ISSN 1872-8952
Keyword(s) Cortical plasticity
Cross-limb transfer
Intracortical inhibition
Ipsilateral motor cortex
Motor practice
tDCS
Summary OBJECTIVE: Age-related neurodegeneration may interfere with the ability to respond to cross-limb transfer, whereby bilateral performance improvements accompany unilateral practice. We investigated whether transcranial direct current stimulation (tDCS) would facilitate this phenomena in older adults. METHODS: 12 young and 12 older adults underwent unilateral visuomotor tracking (VT), with anodal or sham-tDCS over the ipsilateral motor cortex. Transcranial magnetic stimulation (TMS) assessed motor evoked potentials (MEPs) and short interval intracortical inhibition (SICI). Performance was quantified through a VT error. Variables were assessed bilaterally at baseline and post-intervention. RESULTS: The trained limb improved performance, facilitated MEPs and released SICI in both age groups. In the untrained limb, VT improved in young for both sham and anodal-tDCS conditions, but only following anodal-tDCS for the older adults. MEPs increased in all conditions, except the older adult's receiving sham. SICI was released in both tDCS conditions for young and old. CONCLUSION: Following a VT task, older adults still display use-dependent plasticity. Although no significant age-related differences between the outcome measures, older adults exhibited significant cross-limb transfer of performance following anodal-tDCS, which was otherwise absent following motor practice alone. SIGNIFICANCE: These findings provide clinical implications for conditions restricting the use of one limb, such as stroke.
Language eng
DOI 10.1016/j.clinph.2015.01.006
Field of Research 110699 Human Movement and Sports Science not elsewhere classified
Socio Economic Objective 920502 Health Related to Ageing
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2015, Elsevier
Persistent URL http://hdl.handle.net/10536/DRO/DU:30074956

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Created: Tue, 11 Aug 2015, 15:46:31 EST

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