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Do BRCA1 and BRCA2 mutation carriers have earlier natural menopause than their noncarrier relatives? Results from the Kathleen Cuningham Foundation Consortium for research into Familial Breast cancer

Collins, Ian M, Milne, Roger L, McLachlan, Sue Anne, Friedlander, Michael, Hickey, Martha, Weideman, Prue C, Birch, Kate E, Hopper, John L and Phillips, Kelly-Anne 2013, Do BRCA1 and BRCA2 mutation carriers have earlier natural menopause than their noncarrier relatives? Results from the Kathleen Cuningham Foundation Consortium for research into Familial Breast cancer, Journal of clinical oncology, vol. 31, pp. 3920-3925, doi: 10.1200/JCO.2013.49.3007.

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Title Do BRCA1 and BRCA2 mutation carriers have earlier natural menopause than their noncarrier relatives? Results from the Kathleen Cuningham Foundation Consortium for research into Familial Breast cancer
Author(s) Collins, Ian MORCID iD for Collins, Ian M orcid.org/0000-0001-6936-0942
Milne, Roger L
McLachlan, Sue Anne
Friedlander, Michael
Hickey, Martha
Weideman, Prue C
Birch, Kate E
Hopper, John L
Phillips, Kelly-Anne
Journal name Journal of clinical oncology
Volume number 31
Article ID 31
Start page 3920
End page 3925
Total pages 6
Publisher American Society of Clinical Oncology
Place of publication Baltimore, MD
Publication date 2013-11
ISSN 0732-183X
Keyword(s) BRCA1
BRCA2
mutation carriers
natural menopause (NM)
oncology
cancer
Summary PURPOSE: Limited data suggest that germline BRCA1 mutations are associated with occult primary ovarian insufficiency and that BRCA1 and BRCA2 mutation carriers might have earlier natural menopause (NM) than their noncarrier relatives. PATIENTS AND METHODS: Eligible women were mutation carriers and noncarriers from families segregating a BRCA1 or BRCA2 mutation. Data were self-reported using uniform questionnaires at cohort entry and every 3 years thereafter. NM was defined as the cessation of menses for 12 months without another cause. Cox proportional hazards analysis modeled time from birth to NM, adjusting for multiple potential confounders. Analysis time was censored at the earliest of the following: last follow-up, bilateral oophorectomy, hysterectomy, commencement of hormone therapy, insertion of intrauterine device, or any cancer diagnosis. Hazard ratios (HRs) were estimated as a measure of how likely mutation carriers are, relative to noncarriers, to reach NM at a given age. RESULTS: A total of 1,840 women were eligible for analysis. Overall only 19% reached NM. A lower proportion of BRCA1 and BRCA2 mutation carriers reached NM compared with noncarriers. Conversely, a higher proportion of mutation carriers were censored at cancer diagnosis or oophorectomy than noncarriers. The adjusted HR estimates for NM were 1.03 (95% CI, 0.75 to 1.40; P = .9) for 445 BRCA1 mutation carriers and 559 noncarrier relatives and 1.01 (95% CI, 0.71 to 1.42; P = .9) for 374 BRCA2 mutation carriers and 462 noncarrier relatives. CONCLUSION: We found no evidence that BRCA1 and BRCA2 mutation carriers are at higher risk of NM at a given age than their noncarrier relatives.
Language eng
DOI 10.1200/JCO.2013.49.3007
Field of Research 111299 Oncology and Carcinogenesis not elsewhere classified
1112 Oncology And Carcinogenesis
Socio Economic Objective 920102 Cancer and Related Disorders
HERDC Research category C1.1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2013, American Society of Clinical Oncology
Persistent URL http://hdl.handle.net/10536/DRO/DU:30075073

Document type: Journal Article
Collections: Faculty of Health
School of Medicine
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