Preventing breast and ovarian cancers in high-risk BRCA1 and BRCA2 mutation carriers

Collins, Ian M., Milne, Roger L., Weideman, Prue C., McLachlan, Sue-Anne, Friedlander, Michael L., Kathleen Cuningham Foundation Consortium For Research Into Familial Breast, C, Hopper, John L. and Phillips, Kelly-Anne 2013, Preventing breast and ovarian cancers in high-risk BRCA1 and BRCA2 mutation carriers, Medical journal of Australia, vol. 199, no. 10, pp. 680-683, doi: 10.5694/mja13.10848.

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Title Preventing breast and ovarian cancers in high-risk BRCA1 and BRCA2 mutation carriers
Author(s) Collins, Ian M.ORCID iD for Collins, Ian M.
Milne, Roger L.
Weideman, Prue C.
McLachlan, Sue-Anne
Friedlander, Michael L.
Kathleen Cuningham Foundation Consortium For Research Into Familial Breast, C
Hopper, John L.
Phillips, Kelly-Anne
Journal name Medical journal of Australia
Volume number 199
Issue number 10
Start page 680
End page 683
Total pages 4
Publisher Australasian Medical Publishing Company
Place of publication Sydney, N.S.W.
Publication date 2013-11
ISSN 1326-5377
Keyword(s) Adult
Aged, 80 and over
Antineoplastic Agents/therapeutic use
Chemotherapy, Adjuvant/utilization
Female Follow-Up Studies
Genes, BRCA1
Genes, BRCA2
Genetic Markers
Genetic Testing
Kathleen Cuningham Foundation Consortium For Research Into Familial Breast Cancer
Summary OBJECTIVE: To estimate the prevalence of the use of cancer risk-reducing measures among Australian BRCA1 and BRCA2 mutation carriers. DESIGN, SETTING AND
PARTICIPANTS: Prospective follow-up of female carriers of BRCA1 or BRCA2 mutations who had no personal history of cancer and were enrolled in a multiple-case breast cancer family cohort study (kConFab). Data, including cancer events and uptake of risk-reducing surgery and medication were collected by self-report at cohort entry and 3 yearly thereafter. Surgery was confirmed from pathology and medical records. Women were followed up from enrolment until cancer diagnosis, date of last follow-up, or death. Data were collected from 3 November 1997 to 21 May 2012.
MAIN OUTCOME MEASURES: Uptake of risk-reducing surgery and/or medication.
RESULTS: Of 175 BRCA1 and 150 BRCA2 mutation carriers (median age, 37 years at cohort enrolment), 69 (21%) underwent risk-reducing mastectomy, 125 (38%) underwent risk-reducing bilateral salpingo-oophorectomy and nine (3%) participated in a clinical trial of risk-reducing medication, during 2447 person-years of follow-up (median follow-up, 9 years). Sixty-eight women (21%) reported incident cancers, including 52 breast cancers and nine ovarian cancers (defined in this article as high-grade serous cancers of the ovary, fallopian tube or peritoneum).
CONCLUSIONS: There is considerable scope to increase the uptake of cancer risk-reducing measures in Australian BRCA1 and BRCA2 mutation carriers. These findings should drive (i) future research into the factors contributing to low uptake in Australia and (ii) changes to policy and practice to help better translate genetic knowledge into reductions in cancer incidence.
Language eng
DOI 10.5694/mja13.10848
Field of Research 1117 Public Health And Health Services
1103 Clinical Sciences
Socio Economic Objective 0 Not Applicable
HERDC Research category C1.1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2013, Medical Journal of Australia
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Document type: Journal Article
Collection: School of Medicine
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