Development of a resin based silica monolithic column encapsulation Spilstead, Kara B., Haswell, Stephen J., Barnett, Neil W., Conlan, Xavier A., Stevenson, Paul G. and Francis, Paul S. 2015, Development of a resin based silica monolithic column encapsulation, Analytical methods, vol. 7, no. 12, pp. 4908-4911, doi: 10.1039/c5ay00722d. Attached Files Name Description MIMEType Size Downloads spilstead-developmentofa-2015.pdf Published version application/pdf 501.11KB 68 Title Development of a resin based silica monolithic column encapsulation Author(s) Spilstead, Kara B. orcid.org/0000-0003-4599-4136 Haswell, Stephen J. Barnett, Neil W. Conlan, Xavier A. orcid.org/0000-0003-0829-0551 Stevenson, Paul G. orcid.org/0000-0001-6780-6859 Francis, Paul S. orcid.org/0000-0003-4165-6922 Journal name Analytical methods Volume number 7 Issue number 12 Start page 4908 End page 4911 Total pages 4 Publisher Royal Society of Chemistry Place of publication London, Eng. Publication date 2015 ISSN 1759-9660 1759-9679 Keyword(s) Science & Technology Physical Sciences Life Sciences & Biomedicine Technology Chemistry, Analytical Food Science & Technology Spectroscopy Chemistry CHROMATOGRAPHY FLOW Summary As monolithic columns become more extensively used in separation based applications due to their good flow and high surface characteristics, there has arisen the need to establish simple, reliable fabrication methods for fluidic coupling and sealing. In particular, the problem of liquid tracking between a monolith's outer surface and the sealing wall, resulting in poor flow-through performance, needs to be addressed. This paper describes a novel resin-based encapsulation method that penetrates 0.3 mm into the outer surface of a 4 mm diameter monolith, removing the so-called wall-effect. Results based on the peak analysis from 1 μL of 0.4% thiourea injected into a 98:2 water:methanol mobile phase flowing at 1 mL min-1 indicate excellent flow conservation through the monolith. A comparison of peak shape and height equivalent to a theoretical plate (HETP) data between the reported resin-based method and the previously reported heat shrink tubing encapsulation methodology, for the same batch of monoliths, suggests the resin based method offers far superior flow characteristics. In addition to the improved flow properties, the resin casting method enables standard polyether ether ketone (PEEK) fittings to be moulded and subsequently unscrewed from the device offering simple reliable fluidic coupling to be achieved. Language eng DOI 10.1039/c5ay00722d Field of Research 030108 Separation Science 0301 Analytical Chemistry 0399 Other Chemical Sciences Socio Economic Objective 970103 Expanding Knowledge in the Chemical Sciences HERDC Research category C1 Refereed article in a scholarly journal ERA Research output type C Journal article Grant ID ARC DP140100439 Copyright notice ©2015, The Authors Free to Read? Yes Use Rights Persistent URL http://hdl.handle.net/10536/DRO/DU:30075078 Document type: Journal Article Collections: Faculty of Science, Engineering and Built Environment School of Life and Environmental Sciences Open Access Collection Centre for Biotechnology, Chemistry and Systems Biology Related Links Link Description Connect to published version Go to link with your DU access privileges     Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved. Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au. Versions Version Filter Type Fri, 14 Aug 2015, 09:19:22 EST Sat, 15 Aug 2015, 05:04:32 EST Mon, 17 Aug 2015, 08:29:32 EST Thu, 07 Jan 2016, 10:12:57 EST Fri, 08 Jan 2016, 05:06:22 EST Tue, 15 Mar 2016, 09:14:39 EST Tue, 15 Mar 2016, 09:17:18 EST Thu, 25 Jan 2018, 12:44:14 EST Fri, 23 Feb 2018, 09:41:04 EST Fri, 07 Sep 2018, 18:14:18 EST Filtered Full Citation counts:   Cited 1 times in TR Web of Science Cited 1 times in Scopus Search Google Scholar Access Statistics: 480 Abstract Views, 69 File Downloads  -  Detailed Statistics Created: Thu, 07 Jan 2016, 10:12:57 EST

Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.