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Development of a resin based silica monolithic column encapsulation

Spilstead, Kara B., Haswell, Stephen J., Barnett, Neil W., Conlan, Xavier A., Stevenson, Paul G. and Francis, Paul S. 2015, Development of a resin based silica monolithic column encapsulation, Analytical methods, vol. 7, no. 12, pp. 4908-4911, doi: 10.1039/c5ay00722d.

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Title Development of a resin based silica monolithic column encapsulation
Author(s) Spilstead, Kara B.
Haswell, Stephen J.
Barnett, Neil W.
Conlan, Xavier A.ORCID iD for Conlan, Xavier A.
Stevenson, Paul G.ORCID iD for Stevenson, Paul G.
Francis, Paul S.ORCID iD for Francis, Paul S.
Journal name Analytical methods
Volume number 7
Issue number 12
Start page 4908
End page 4911
Total pages 4
Publisher Royal Society of Chemistry
Place of publication London, Eng.
Publication date 2015
ISSN 1759-9660
Keyword(s) Science & Technology
Physical Sciences
Life Sciences & Biomedicine
Chemistry, Analytical
Food Science & Technology
Summary As monolithic columns become more extensively used in separation based applications due to their good flow and high surface characteristics, there has arisen the need to establish simple, reliable fabrication methods for fluidic coupling and sealing. In particular, the problem of liquid tracking between a monolith's outer surface and the sealing wall, resulting in poor flow-through performance, needs to be addressed. This paper describes a novel resin-based encapsulation method that penetrates 0.3 mm into the outer surface of a 4 mm diameter monolith, removing the so-called wall-effect. Results based on the peak analysis from 1 μL of 0.4% thiourea injected into a 98:2 water:methanol mobile phase flowing at 1 mL min-1 indicate excellent flow conservation through the monolith. A comparison of peak shape and height equivalent to a theoretical plate (HETP) data between the reported resin-based method and the previously reported heat shrink tubing encapsulation methodology, for the same batch of monoliths, suggests the resin based method offers far superior flow characteristics. In addition to the improved flow properties, the resin casting method enables standard polyether ether ketone (PEEK) fittings to be moulded and subsequently unscrewed from the device offering simple reliable fluidic coupling to be achieved.
Language eng
DOI 10.1039/c5ay00722d
Field of Research 030108 Separation Science
0301 Analytical Chemistry
0399 Other Chemical Sciences
Socio Economic Objective 970103 Expanding Knowledge in the Chemical Sciences
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Grant ID DP140100439
Copyright notice ©2015, Royal Society of Chemistry
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Created: Thu, 07 Jan 2016, 10:12:57 EST

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