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Oxidative stress and post-stroke depression: possible therapeutic role of polyphenols?

Nabavi, Seyed Fazel, Dean, Olivia M., Turner, Alyna, Sureda, Antoni, Daglia, Maria and Nabavi, Seyed Mohammad 2015, Oxidative stress and post-stroke depression: possible therapeutic role of polyphenols?, Current medicinal chemistry, vol. 22, no. 3, pp. 343-351, doi: 10.2174/0929867321666141106122319.

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Title Oxidative stress and post-stroke depression: possible therapeutic role of polyphenols?
Author(s) Nabavi, Seyed Fazel
Dean, Olivia M.ORCID iD for Dean, Olivia M. orcid.org/0000-0002-2776-3935
Turner, AlynaORCID iD for Turner, Alyna orcid.org/0000-0001-7389-2546
Sureda, Antoni
Daglia, Maria
Nabavi, Seyed Mohammad
Journal name Current medicinal chemistry
Volume number 22
Issue number 3
Start page 343
End page 351
Total pages 9
Publisher Bentham Science Publishers
Place of publication Beijing, China
Publication date 2015
ISSN 1875-533X
Keyword(s) animals
antioxidants
depression
humans
oxidative stress
polyphenols
stroke
major depressive disorder
post-stroke depression
Summary Post-stroke depression is a common neuropsychiatric affective disorder that may develop after a stroke event. In addition to abnormalities in the biogenic amine neurotransmitters and cytokine expression induced by stroke we will focus on the role of oxidative stress and hypothesize that polyphenols may be useful as therapeutics targets for the treatment of post-stroke depression. In this paper, we discuss the hypothesis that increased oxidative stress in cerebral tissues during ischemia is implicated in the pathogenesis of depressive-like symptoms following stroke. There is substantive evidence regarding the role of oxidative stress in the pathogenesis of both stroke and depression, which provides support to this hypothesis. Reactive oxygen species, generated during stroke, cause oxidative stress, lipid peroxidation, protein oxidation, and DNA damage in neural tissues. The resultant pathophysiological processes in the neural tissues could be considered a leading mechanism in the induction of post-stroke depression. Antioxidants including polyphenols therefore, may play an important role in the outcomes of ischemia and stroke, due to their ability to protect neurons against oxidative stress, to mitigate ischemic damage via inhibition of lipid peroxidation and ability to interact with the generation of nitric oxide from the vascular endothelium, and also to decrease inflammation. These data suggest that polyphenols may therefore be a useful new therapeutic target for the treatment of post-stroke depression.
Language eng
DOI 10.2174/0929867321666141106122319
Field of Research 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified
0304 Medicinal And Biomolecular Chemistry
1115 Pharmacology And Pharmaceutical Sciences
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2015, Bentham Science Publishers
Persistent URL http://hdl.handle.net/10536/DRO/DU:30075138

Document type: Journal Article
Collection: School of Medicine
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Created: Fri, 14 Aug 2015, 10:48:01 EST

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