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Cytokine expression and secretion by skeletal muscle cells: regulatory mechanisms and exercise effects

Peake, Jonathan M., Della Gatta, Paul, Suzuki, , Katsuhiko and Nieman, David C. 2015, Cytokine expression and secretion by skeletal muscle cells: regulatory mechanisms and exercise effects, Exercise immunology review, vol. 21, pp. 8-25.

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Title Cytokine expression and secretion by skeletal muscle cells: regulatory mechanisms and exercise effects
Author(s) Peake, Jonathan M.
Della Gatta, PaulORCID iD for Della Gatta, Paul orcid.org/0000-0003-2231-8370
Suzuki, , Katsuhiko
Nieman, David C.
Journal name Exercise immunology review
Volume number 21
Start page 8
End page 25
Total pages 18
Publisher Association for the Advancement of Sports Medicine
Place of publication Champaign, Ill.
Publication date 2015
ISSN 1077-5552
Keyword(s) Animals
Cells, Cultured
Cytokines
Exercise
Fibroblasts
Gene Expression Regulation
Humans
Interleukin-6
Motor Activity
Muscle Fibers, Skeletal
Muscle Proteins
Myeloid Cells
Myoblasts
Organ specificity
Physical Exertion
RNA, Messenger
RNA-Binding Proteins
Receptors, Cytokine
Running
Summary Cytokines are important mediators of various aspects of health and disease, including appetite, glucose and lipid metabolism, insulin sensitivity, skeletal muscle hypertrophy and atrophy. Over the past decade or so, considerable attention has focused on the potential for regular exercise to counteract a range of disease states by modulating cytokine production. Exercise stimulates moderate to large increases in the circulating concentrations of interleukin (IL)-6, IL-8, IL- 10, IL-1 receptor antagonist, granulocyte-colony stimulating factor, and smaller increases in tumor necrosis factor-α, monocyte chemotactic protein-1, IL-1β, brain-derived neurotrophic factor, IL-12p35/p40 and IL-15. Although many of these cytokines are also expressed in skeletal muscle, not all are released from skeletal muscle into the circulation during exercise. Conversely, some cytokines that are present in the circulation are not expressed in skeletal muscle after exercise. The reasons for these discrepant cytokine responses to exercise are unclear. In this review, we address these uncertainties by summarizing the capacity of skeletal muscle cells to produce cytokines, analyzing other potential cellular sources of circulating cytokines during exercise, and discussing the soluble factors and intracellular signaling pathways that regulate cytokine synthesis (e.g., RNA-binding proteins, microRNAs, suppressor of cytokine signaling proteins, soluble receptors).
Language eng
Field of Research 110699 Human Movement and Sports Science not elsewhere classified
Socio Economic Objective 929999 Health not elsewhere classified
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2015, Association for the Advancement of Sports Medicine
Persistent URL http://hdl.handle.net/10536/DRO/DU:30075141

Document type: Journal Article
Collection: School of Exercise and Nutrition Sciences
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Created: Thu, 10 Sep 2015, 15:39:58 EST

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