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A new restriction fragment length polymorphism in the first intron of the spontaneously hypertensive rat renin gene

Wang, D. Z., Wilks, A., Morgan, T. O. and Di Nicolantonio, R. 1994, A new restriction fragment length polymorphism in the first intron of the spontaneously hypertensive rat renin gene, Clinical and experimental pharmacology and physiology, vol. 21, no. 4, pp. 339-341, doi: 10.1111/j.1440-1681.1994.tb02524.x.

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Title A new restriction fragment length polymorphism in the first intron of the spontaneously hypertensive rat renin gene
Author(s) Wang, D. Z.
Wilks, A.
Morgan, T. O.
Di Nicolantonio, R.ORCID iD for Di Nicolantonio, R. orcid.org/0000-0003-0866-4410
Journal name Clinical and experimental pharmacology and physiology
Volume number 21
Issue number 4
Start page 339
End page 341
Total pages 3
Publisher John Wiley & Sons
Place of publication Chichester, Eng.
Publication date 1994-04
ISSN 0305-1870
Keyword(s) Animals
Base Sequence
Introns
Molecular Sequence Data
Polymorphism, Restriction Fragment Length
Rats
Rats, Inbred SHR
Rats, Inbred WKY
Rats, Sprague-Dawley
Renin
Repetitive Sequences, Nucleic Acid
Summary 1. Amplification of the entire first intron of the renin gene of spontaneously hypertensive rat (SHR), Wistar-Kyoto (WKY) and Sprague-Dawley rats (SD) followed by Bgl II digestion uncovered a new deletion (approximately 50 bp) which exists upstream of the SHR renin gene first intron tandem repeat element. 2. The SHR tandem repeat element was 600 bp shorter than that in the WKY while the WKY tandem repeat element was 280 bp shorter than that in the SD. 3. Since elements regulating gene expression are known to exist in the first intron of other genes, this new restriction fragment length polymorphism (RFLP) might play a role in the reported overexpression of the SHR renin gene independent of changes in the length of the tandem repeat element.
Language eng
DOI 10.1111/j.1440-1681.1994.tb02524.x
Field of Research 0606 Physiology
1115 Pharmacology And Pharmaceutical Sciences
1116 Medical Physiology
HERDC Research category CN.1 Other journal article
Copyright notice ©1994, John Wiley & Sons
Free to Read? Yes
Persistent URL http://hdl.handle.net/10536/DRO/DU:30075207

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Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.