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Dietary micronutrients and in vivo n-3 LC-PUFA biosynthesis in Atlantic salmon

Giri, Shiba S., Graham, Jeffrey, Hamid, Noor K.A., Donald, John A. and Turchini, Giovanni M. 2016, Dietary micronutrients and in vivo n-3 LC-PUFA biosynthesis in Atlantic salmon, Aquaculture, vol. 452, pp. 416-425, doi: 10.1016/j.aquaculture.2015.05.022.

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Title Dietary micronutrients and in vivo n-3 LC-PUFA biosynthesis in Atlantic salmon
Author(s) Giri, Shiba S.
Graham, Jeffrey
Hamid, Noor K.A.
Donald, John A.ORCID iD for Donald, John A. orcid.org/0000-0001-5930-2642
Turchini, Giovanni M.ORCID iD for Turchini, Giovanni M. orcid.org/0000-0003-0694-4283
Journal name Aquaculture
Volume number 452
Start page 416
End page 425
Total pages 10
Publisher Elsevier
Place of publication Amsterdam, The Netherlands
Publication date 2016-02-01
ISSN 0044-8486
Keyword(s) iron
zinc
magnesium
riboflavin
biotin
niacin
ALA
EPA
DHA
Science & Technology
Life Sciences & Biomedicine
Fisheries
Marine & Freshwater Biology
FATTY-ACID-COMPOSITION
TROUT ONCORHYNCHUS-MYKISS
CHAIN OMEGA-3 OILS
RAT-LIVER MICROSOMES
FISH-OIL
RAINBOW-TROUT
SALAR L.
DOCOSAHEXAENOIC ACID
GROWTH-PERFORMANCE
LIPID-METABOLISM
Summary Aquaculture, and in particular Atlantic salmon culture, is expected to deliver n. -3 long-chain polyunsaturated fatty acid (n. -3 LC-PUFA) rich products. Nevertheless, the availability of n. -3 LC-PUFA rich raw materials for aquafeed is dwindling, and at an ever increasing market price. Thus, there is the need to better understand the in vivo n. -3 LC-PUFA biosynthetic capabilities of cultured fish to enable the possible maximization of dietary 18:3n. -3 (ALA) bioconversion to 20:5n. -3 (EPA) and 22:6n. -3 (DHA). The cofactors and coenzymes involved in this metabolic pathway have so far received limited research attention. In this study, juvenile Atlantic salmon were fed an ALA-rich diet with no, normal, or over-fortified inclusion of those micronutrients reported to be essential cofactors (iron; zinc; magnesium) and coenzymes (riboflavin; biotin; niacin) for the fatty acid elongase and desaturase enzymes. The results showed that reduced dietary inclusion of these micronutrients impaired the normal n. -3 LC-PUFA biosynthetic capabilities of fish, whereas the over fortification did not provide any additional benefit. This study provides new knowledge on micronutrients and lipid metabolism interactions in a commercially important cultured species, and is envisaged to be a useful contribution towards developing more sustainable and commercially viable aquafeed for the future.Statement of relevance. This work is the continuation and extension of a previous study (Lewis et al., 2013, Aquaculture 412/413, 215-222) in which we explored the physiological roles and potential effects of micronutrients on fatty acid metabolism in cultured fish. The present study differed from the previous in the blend of minerals and vitamins used, the species, the fatty acid composition of the test diet, and the inclusion also of a negative control. The results are most interesting, showing that riboflavin (B2), biotin (B7), and niacin (B3), Iron (Fe), Magnesium (Mg) and Zinc (Zn) are all required for proper fatty acid bioconversion, but also that a dietary over-fortification does not translate into proportional improved bioconversion.
Language eng
DOI 10.1016/j.aquaculture.2015.05.022
Field of Research 070401 Aquaculture
0704 Fisheries Sciences
0608 Zoology
Socio Economic Objective 830102 Aquaculture Fin Fish (excl. Tuna)
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2016, Elsevier
Persistent URL http://hdl.handle.net/10536/DRO/DU:30075283

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