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Chemiluminescence detection of MDMA in street drug samples using tris (2,2'-bipyridine) ruthenium (III)

Theakstone, Ashton G., Smith, Zoe M., Terry, Jessica M., Barnett, Neil W. and Francis, Paul S. 2015, Chemiluminescence detection of MDMA in street drug samples using tris (2,2'-bipyridine) ruthenium (III), Drug testing and analysis, vol. 7, no. 5, pp. 428-432, doi: 10.1002/dta.1780.

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Title Chemiluminescence detection of MDMA in street drug samples using tris (2,2'-bipyridine) ruthenium (III)
Author(s) Theakstone, Ashton G.
Smith, Zoe M.
Terry, Jessica M.
Barnett, Neil W.
Francis, Paul S.ORCID iD for Francis, Paul S. orcid.org/0000-0003-4165-6922
Journal name Drug testing and analysis
Volume number 7
Issue number 5
Start page 428
End page 432
Total pages 5
Publisher Wiley
Place of publication London, Eng.
Publication date 2015-05
ISSN 1942-7611
Keyword(s) MDMA
amphetamine derivatives
chemiluminescence detection
high performance liquid chromatography
street drug samples
Science & Technology
Life Sciences & Biomedicine
Physical Sciences
Biochemical Research Methods
Chemistry, Analytical
Pharmacology & Pharmacy
Biochemistry & Molecular Biology
Chemistry
FLOW-INJECTION ANALYSIS
ECSTASY TABLETS
TRIS(2,2'-BIPYRIDYL)RUTHENIUM(II) CHEMILUMINESCENCE
TRIS(2,2'-BIPYRIDINE)RUTHENIUM(III)
COLUMN
Summary Tris(2,2'-bipyridine)ruthenium(II) chemiluminescence was investigated for the detection of 3,4-methylenedioxymethamphetamine (MDMA) and several related compounds in street drug samples. Optimization using flow injection analysis showed that the selectivity of the reagent can be targeted towards the detection of secondary amines by altering the pH of the reaction environment. The greater selectivity of this mode of detection, compared to UV-absorbance, reduces the probability of false positive results from interfering compounds. The detection limit for MDMA under these conditions was 0.48 μM. A HPLC method incorporating post-column tris(2,2'-bipyridine)ruthenium(II) chemiluminescence detection was applied to the determination of MDMA in five street drug samples. The results obtained were in good agreement with quantification performed using traditional UV-absorbance detection, which demonstrates the viability of this method for confirmatory analysis of drug samples. This is the first report of tris(2,2'-bipyridine)ruthenium(II) chemiluminescence for the detection of MDMA and related amphetamine derivatives.
Language eng
DOI 10.1002/dta.1780
Field of Research 030108 Separation Science
030103 Flow Analysis
0301 Analytical Chemistry
1115 Pharmacology And Pharmaceutical Sciences
Socio Economic Objective 970103 Expanding Knowledge in the Chemical Sciences
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Grant ID LP130100681
Copyright notice ©2015, Wiley
Persistent URL http://hdl.handle.net/10536/DRO/DU:30075422

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