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Current markers of the Athlete Blood Passport do not flag microdose EPO doping

Ashenden, Michael, Gough, Clare E., Garnham, Andrew, Gore, Christopher J. and Sharpe, Ken 2011, Current markers of the Athlete Blood Passport do not flag microdose EPO doping, European journal of applied physiology, vol. 111, no. 9, pp. 2307-2314, doi: 10.1007/s00421-011-1867-6.

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Title Current markers of the Athlete Blood Passport do not flag microdose EPO doping
Author(s) Ashenden, Michael
Gough, Clare E.
Garnham, Andrew
Gore, Christopher J.
Sharpe, Ken
Journal name European journal of applied physiology
Volume number 111
Issue number 9
Start page 2307
End page 2314
Total pages 8
Publisher Springer-Verlag
Place of publication Heidelberg, Germany
Publication date 2011-09
ISSN 1439-6319
1439-6327
Keyword(s) blood doping
reticulocytes
Sysmex
erythropoietin
Adult
Athletes
Biomarkers
Doping in Sports
Dose-Response Relationship, Drug
Humans
Limit of Detection
Male
Performance-Enhancing Substances
Recombinant Proteins
Reference Values
Resistance Training
Sensitivity and Specificity
Substance Abuse Detection
Young Adult
Science & Technology
Life Sciences & Biomedicine
Physiology
Sport Sciences
RECOMBINANT-HUMAN-ERYTHROPOIETIN
ABUSE
HEMOGLOBIN
EXERCISE
VALUES
Summary The Athlete Blood Passport is the most recent tool adopted by anti-doping authorities to detect athletes using performance-enhancing drugs such as recombinant human erythropoietin (rhEPO). This strategy relies on detecting abnormal variations in haematological variables caused by doping, against a background of biological and analytical variability. Ten subjects were given twice weekly intravenous injections of rhEPO for up to 12 weeks. Full blood counts were measured using a Sysmex XE-2100 automated haematology analyser, and total haemoglobin mass via a carbon monoxide rebreathing test. The sensitivity of the passport to flag abnormal deviations in blood values was evaluated using dedicated Athlete Blood Passport software. Our treatment regimen elicited a 10% increase in total haemoglobin mass equivalent to approximately two bags of reinfused blood. The passport software did not flag any subjects as being suspicious of doping whilst they were receiving rhEPO. We conclude that it is possible for athletes to use rhEPO without eliciting abnormal changes in the blood variables currently monitored by the Athlete Blood Passport.
Language eng
DOI 10.1007/s00421-011-1867-6
Field of Research 110604 Sports Medicine
1106 Human Movement And Sports Science
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2011, Springer-Verlag
Persistent URL http://hdl.handle.net/10536/DRO/DU:30075451

Document type: Journal Article
Collection: School of Exercise and Nutrition Sciences
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