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Low muscle glycogen concentration does not suppress the anabolic response to resistance exercise

Camera, Donny M., West, Daniel W. D., Burd, Nicholas A., Phillips, Stuart M., Garnham, Andrew P., Hawley, John A. and Coffey, Vernon G. 2012, Low muscle glycogen concentration does not suppress the anabolic response to resistance exercise, Journal of applied physiology, vol. 113, no. 2, pp. 206-214, doi: 10.1152/japplphysiol.00395.2012.

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Title Low muscle glycogen concentration does not suppress the anabolic response to resistance exercise
Author(s) Camera, Donny M.
West, Daniel W. D.
Burd, Nicholas A.
Phillips, Stuart M.
Garnham, Andrew P.
Hawley, John A.
Coffey, Vernon G.
Journal name Journal of applied physiology
Volume number 113
Issue number 2
Start page 206
End page 214
Total pages 9
Publisher American Physiological Society
Place of publication Bethesda, Md.
Publication date 2012-07-15
ISSN 8750-7587
1522-1601
Keyword(s) skeletal muscle
muscle protein synthesis
Anabolic Agents
Exercise Tolerance
Glycogen
Humans
Insulin
Male
Muscle, Skeletal
Oxygen Consumption
Reference Values
Resistance Training
Young Adult
Summary We determined the effect of muscle glycogen concentration and postexercise nutrition on anabolic signaling and rates of myofibrillar protein synthesis after resistance exercise (REX). Sixteen young, healthy men matched for age, body mass, peak oxygen uptake (Vo2peak) and strength (one repetition maximum; 1RM) were randomly assigned to either a nutrient or placebo group. After 48 h diet and exercise control, subjects undertook a glycogen-depletion protocol consisting of one-leg cycling to fatigue (LOW), whereas the other leg rested (NORM). The next morning following an overnight fast, a primed, constant infusion of l-[ring-13C6] phenylalanine was commenced and subjects completed 8 sets of 5 unilateral leg press repetitions at 80% 1RM. Immediately after REX and 2 h later, subjects consumed a 500 ml bolus of a protein/CHO (20 g whey + 40 g maltodextrin) or placebo beverage. Muscle biopsies from the vastus lateralis of both legs were taken at rest and 1 and 4 h after REX. Muscle glycogen concentration was higher in the NORM than LOW at all time points in both nutrient and placebo groups (P < 0.05). Postexercise Akt-p70S6K-rpS6 phosphorylation increased in both groups with no differences between legs (P < 0.05). mTORSer2448 phosphorylation in placebo increased 1 h after exercise in NORM (P < 0.05), whereas mTOR increased ~4-fold in LOW (P < 0.01) and ~11 fold in NORM with nutrient (P < 0.01; different between legs P < 0.05). Post-exercise rates of MPS were not different between NORM and LOW in nutrient (0.070 ± 0.022 vs. 0.068 ± 0.018 %/h) or placebo (0.045 ± 0.021 vs. 0.049 ± 0.017 %/h). We conclude that commencing high-intensity REX with low muscle glycogen availability does not compromise the anabolic signal and subsequent rates of MPS, at least during the early (4 h) postexercise recovery period.
Language eng
DOI 10.1152/japplphysiol.00395.2012
Field of Research 110699 Human Movement and Sports Science not elsewhere classified
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2012, American Physiological Society
Persistent URL http://hdl.handle.net/10536/DRO/DU:30075455

Document type: Journal Article
Collections: Faculty of Health
School of Exercise and Nutrition Sciences
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