Metabotropic glutamate receptors as targets for novel antipsychotic treatments

Gray, L. J., Hannan, A. J. and Zhang, X. 2012, Metabotropic glutamate receptors as targets for novel antipsychotic treatments, Current pharmaceutical biotechnology, vol. 13, no. 8, pp. 1522-1534, doi: 10.2174/138920112800784817#sthash.6cMl8GJn.dpuf.

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Title Metabotropic glutamate receptors as targets for novel antipsychotic treatments
Author(s) Gray, L. J.ORCID iD for Gray, L. J. orcid.org/0000-0002-7903-5796
Hannan, A. J.
Zhang, X.
Journal name Current pharmaceutical biotechnology
Volume number 13
Issue number 8
Start page 1522
End page 1534
Total pages 13
Publisher Bentham Science Publishers
Place of publication Amsterdam, The Netherlands
Publication date 2012-06
ISSN 1873-4316
Keyword(s) Antipsychotic
Metabotropic glutamate receptors
mGluR2
mGluR3
mGluR5
Science & Technology
Life Sciences & Biomedicine
Biochemistry & Molecular Biology
Pharmacology & Pharmacy
POSITIVE ALLOSTERIC MODULATOR
LONG-TERM POTENTIATION
ADENOSINE A(2A) RECEPTORS
PROTEIN-KINASE-C
DORSOLATERAL PREFRONTAL CORTEX
PREPULSE INHIBITION DEFICIT
CENTRAL-NERVOUS-SYSTEM
RAT DORSAL STRIATUM
GROUP-I
NMDA RECEPTOR
Summary In recent years metabotropic glutamate receptors have emerged as key targets for the design of new antipsychotic medications for schizophrenia, in particular mGluR5 and mGluR2/3. These receptors exhibit diverse interactions with other neurotransmitter receptors and critical elements of intracellular signalling cascades known to be important to the pharmacotherapy of schizophrenia. In addition, mGluR5 and mGluR2/3 are intimately involved in behavioural domains related to the symptoms of this disorder. Both animal and clinical studies using novel drugs targeting these receptors have provided encouraging results. The number of patents registered for drugs targeting metabotropic glutamate receptors has grown dramatically, and positive allosteric modulators for both receptors show particular promise.
Language eng
DOI 10.2174/138920112800784817#sthash.6cMl8GJn.dpuf
Field of Research 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2012, Bentham Science Publishers
Persistent URL http://hdl.handle.net/10536/DRO/DU:30075518

Document type: Journal Article
Collection: School of Medicine
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