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N-Ethylmaleimide sensitive factor in the cortex of subjects with schizophrenia and bipolar I disorder

Gray, Laura, Scarr, Elizabeth and Dean, Brian 2006, N-Ethylmaleimide sensitive factor in the cortex of subjects with schizophrenia and bipolar I disorder, Neuroscience letters, vol. 391, no. 3, pp. 112-115, doi: 10.1016/j.neulet.2005.08.051.

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Title N-Ethylmaleimide sensitive factor in the cortex of subjects with schizophrenia and bipolar I disorder
Author(s) Gray, Laura
Scarr, Elizabeth
Dean, Brian
Journal name Neuroscience letters
Volume number 391
Issue number 3
Start page 112
End page 115
Total pages 4
Publisher Elsevier
Place of publication Amsterdam, The Netherlands
Publication date 2006-01-02
ISSN 0304-3940
Keyword(s) NSF
Schizophrenia
Bipolar disorder
Synapse
Presynaptic protein
Frontal cortex
Summary N-Ethylmaleimide sensitive factor (NSF) is a presynaptic protein that has been suggested to be differentially expressed in the cortex of schizophrenic subjects through both high-throughput proteomic and genomic screening studies. Thus, to expand upon these studies we measured NSF using Western blotting in four regions of the cortex (BA9, 10, 40 and 46), in a cohort comprising 20 schizophrenic subjects, 8 bipolar I disorder subjects, and 20 control subjects. There was no significant difference in NSF levels between diagnostic cohorts in any of the four cortical regions. These findings highlight the importance of validating findings from high-throughput screening studies and do not support changes in cortical NSF as being of significance in schizophrenia or bipolar 1 disorder.
Language eng
DOI 10.1016/j.neulet.2005.08.051
Field of Research 110999 Neurosciences not elsewhere classified
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2006, Eselvier
Persistent URL http://hdl.handle.net/10536/DRO/DU:30075525

Document type: Journal Article
Collection: School of Medicine
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