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Regionally specific changes in levels of cortical S100β in bipolar 1 disorder but not schizophrenia

Dean, Brian, Gray, Laura and Scarr, Elizabeth 2006, Regionally specific changes in levels of cortical S100β in bipolar 1 disorder but not schizophrenia, Australian and New Zealand journal of psychiatry, vol. 40, no. 3, pp. 217-224, doi: 10.1080/j.1440-1614.2006.01777.x.

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Title Regionally specific changes in levels of cortical S100β in bipolar 1 disorder but not schizophrenia
Author(s) Dean, Brian
Gray, Laura
Scarr, Elizabeth
Journal name Australian and New Zealand journal of psychiatry
Volume number 40
Issue number 3
Start page 217
End page 224
Total pages 8
Publisher Sage Publications
Place of publication London, Eng.
Publication date 2006-03
ISSN 0004-8674
1440-1614
Summary Objective: To determine if levels of the glial-derived proteins S100β and glial acidic fibrillary protein (GFAP) and the pro- and antiapoptotic proteins p53 and Bcl-2 were altered in the cortex of subjects with schizophrenia or bipolar 1 disorder.
Method: Levels of S100β, GFAP, p53 and Bcl-2 were measured in cortex (Brodmann's Areas (BAs) 9, 10, 46 and 40) of control subjects and subjects with schizophrenia, bipolar 1 disorder and in the cortex of rats treated with haloperidol or lithium using protein-specific antibodies and western blot analysis.
Results: Levels of S100β were decreased in BA 9 and increased in BA 40 from subjects with bipolar 1 disorder. Levels of this protein were not altered in other CNS regions, in schizophrenia or in the cortex of rats treated with haloperidol or lithium. No changes in levels of the other three proteins were detected across diagnoses.
Conclusions: Regionally selective changes in cortical S100β may be associated with the pathology of bipolar 1 disorder and may reflect derangements in neuronal death or survival
Language eng
DOI 10.1080/j.1440-1614.2006.01777.x
Field of Research 110999 Neurosciences not elsewhere classified
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2006, Sage
Persistent URL http://hdl.handle.net/10536/DRO/DU:30075526

Document type: Journal Article
Collection: School of Medicine
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