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A comparison of M1 and M4 muscarinic receptors in the thalamus from control subjects and subjects with schizophrenia

Dean, B., Gray, L., Keriakous, D. and Scarr, E. 2004, A comparison of M1 and M4 muscarinic receptors in the thalamus from control subjects and subjects with schizophrenia, Thalamus & related systems, vol. 2, no. 4, pp. 287-295, doi: 10.1016/j.tharel.2003.12.001.

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Title A comparison of M1 and M4 muscarinic receptors in the thalamus from control subjects and subjects with schizophrenia
Author(s) Dean, B.
Gray, L.
Keriakous, D.
Scarr, E.
Journal name Thalamus & related systems
Volume number 2
Issue number 4
Start page 287
End page 295
Total pages 9
Publisher Eselvier
Place of publication Amsterdam, The Netherlands
Publication date 2004-07
ISSN 1472-9288
Keyword(s) Postmortem
Thalamus
Human
Acetylcholine
Muscarinic receptors
Summary Having shown a decrease in muscarinic M1 receptors in Brodmann’s area (BA) 9 from subjects with schizophrenia we have extended our studies to determine if this receptor is decreased in the thalamus from the same cohort of subjects. Levels of Full-size image (<1 K)pirenzepine binding to and mRNA encoding for M1 and M4 receptors were measured throughout the thalamus. Levels of M1 and M4 receptor proteins were measured in the mediodorsal nucleus. Two-way ANOVA revealed a variance in Full-size image (<1 K)pirenzepine binding (F=4.69, d.f. = 1.190, P=0.03), but there was no significant change in radioligand binding in any thalamic region in schizophrenia. Neither levels of mRNA encoding the thalamic M1 or M4 receptor nor levels of M1 or M4 receptor protein in the mediodorsal nucleus differed between the schizophrenic and control subjects. We therefore conclude that the M1 and M4 receptor are not altered in the thalamus from subjects with schizophrenia. These data add weight to the hypothesis that changes in M1 receptors in selective regions of the CNS are associated with the pathology of schizophrenia.
Language eng
DOI 10.1016/j.tharel.2003.12.001
Field of Research 110999 Neurosciences not elsewhere classified
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2004, Elsevier
Persistent URL http://hdl.handle.net/10536/DRO/DU:30075527

Document type: Journal Article
Collection: School of Medicine
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